一起新型冠状病毒肺炎家族聚集性疫情流行病学调查分析

管群; 刘淼; 庄英杰; 袁月; 王盛书; 李进; 陈竹; 杨兴龙; 汤紫荣; 贾红军; 马婧怡; 王晓霞; 台朋岗; 李靖; 何耀

Abstract

管群,刘淼,庄英杰,袁月,王盛书,李进,陈竹,杨兴龙,汤紫荣,贾红军,马婧怡,王晓霞,台朋岗,李靖,何耀.一起新型冠状病毒肺炎家族聚集性疫情流行病学调查分析[J].Chinese journal of Epidemiology,2020,41(5):629-633

一起新型冠状病毒肺炎家族聚集性疫情流行病学调查分析

Epidemiological investigation of a family clustering of COVID-19

Received:February 23, 2020

DOI：10.3760/cma.j.cn112338-20200223-00152

KeyWord: 新型冠状病毒肺炎家庭聚集性流行病学

English Key Word: COVID-19 Family clustering Epidemiological investigation

FundProject:全军应急科研管理课题；解放军总医院应急科研攻关课题（20EP008）

Author Name	Affiliation	E-mail
Guan Qun	The Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China
Liu Miao	Institute of Geriatrics, Second Medical Center, National Clinical Research Center for Geriatrics Diseases, Beijing Key Laboratory of Aging and Geriatrics, Chinese People's Liberation Army General Hospital, Beijing 100083, China
Zhuang Yingjie	The Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China
Yuan Yue	The Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China
Wang Shengshu	Institute of Geriatrics, Second Medical Center, National Clinical Research Center for Geriatrics Diseases, Beijing Key Laboratory of Aging and Geriatrics, Chinese People's Liberation Army General Hospital, Beijing 100083, China
Li Jin	The Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China
Chen Zhu	The Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China
Yang Xinglong	The Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China
Tang Zirong	The Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China
Jia Hongjun	The Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China
Ma Jingyi	The Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China
Wang Xiaoxia	The Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China
Tai Penggang	Medical Service Department, Chinese People's Liberation Army General Hospital, Beijing 100083, China
Li Jing	The Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China	1339590718@qq.com
He Yao	Institute of Geriatrics, Second Medical Center, National Clinical Research Center for Geriatrics Diseases, Beijing Key Laboratory of Aging and Geriatrics, Chinese People's Liberation Army General Hospital, Beijing 100083, China	yhe301@x263.net

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Abstract:

目的通过对1起家庭聚集性新型冠状病毒肺炎8例病例的流行病学调查分析，探讨流行病学特征，为新型冠状病毒肺炎的防控提供依据。方法采用描述性流行病学方法开展调查。结果经调查来京湖北籍长居人员病例1为此次聚集病例的传染源，在整个潜伏期内共传染二代病例6人（病例2至病例7）。出现三代疑似病例1例。二代病例中有3例在暴露14 d后发病。指示病例1传染到二代病例6的途径为近距离的呼吸道飞沫传播，指示病例1传染到家庭二代病例的途径包括呼吸道飞沫传播和密切接触传播2种方式。全年龄段人群普遍易感。症状方面，老年人群病情较重，青年人群症状较轻。除了呼吸道症状，腹泻等消化道症状、乏力肌肉酸痛头痛等其他症状也不容忽视。结论家庭聚集性发病是新型冠状病毒肺炎疫情防控的重点。

English Abstract:

Objective To investigate the epidemiological characteristics of a family clustering of COVID-19. Methods Field epidemiological survey was conducted. Results Case 1 of the long-term residents from Hubei province was the source of infection of this family clustering. There were 6 cases (from case 2 to case 7) infected in the whole incubation period. The incubation period was more than 14 days for 3 of the second-generation cases. Routes of transmission included respiratory droplets (from case 1 transmitted to case 6, from case 1 to her family members) and close contact (from case 1 to other cases in her family). All the age groups were generally susceptible, while elderly were easier to progress to critically ill. Besides respiratory symptoms, there were also gastrointestinal symptoms, of which diarrhea was the most common one. Conclusions Family clustering had been an important part for COVID-19 cases.

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