Abstract
陈奕,王爱红,易波,丁克琴,王海波,王建美,史宏博,王思嘉,许国章.宁波市新型冠状病毒肺炎密切接触者感染流行病学特征分析[J].Chinese journal of Epidemiology,2020,41(5):667-671
宁波市新型冠状病毒肺炎密切接触者感染流行病学特征分析
Epidemiological characteristics of infection in COVID-19 close contacts in Ningbo city
Received:March 04, 2020  
DOI:10.3760/cma.j.cn112338-20200304-00251
KeyWord: 新型冠状病毒肺炎;密切接触者;流行病学特征;感染率
English Key Word: COVID-19;Close contacts;Epidemiological characteristics;Infection rate
FundProject:宁波市科技重大专项-新型冠状病毒肺炎疫情防控应急科技攻关项目(2020C50001);宁波市医疗卫生品牌学科(PPXK2018-10);浙江省医学重点学科(07-013)
Author NameAffiliationE-mail
Chen Yi Department of Communicable Disease Control and Prevention, Department of Occupational Health and Environmental Health, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo 315010, China  
Wang Aihong Department of Communicable Disease Control and Prevention, Department of Occupational Health and Environmental Health, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo 315010, China  
Yi Bo Department of Communicable Disease Control and Prevention, Department of Occupational Health and Environmental Health, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo 315010, China  
Ding Keqin Department of Communicable Disease Control and Prevention, Department of Occupational Health and Environmental Health, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo 315010, China  
Wang Haibo Department of Communicable Disease Control and Prevention, Department of Occupational Health and Environmental Health, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo 315010, China  
Wang Jianmei Department of Communicable Disease Control and Prevention, Department of Occupational Health and Environmental Health, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo 315010, China  
Shi Hongbo Department of Communicable Disease Control and Prevention, Department of Occupational Health and Environmental Health, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo 315010, China  
Wang Sijia Department of Communicable Disease Control and Prevention, Department of Occupational Health and Environmental Health, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo 315010, China  
Xu Guozhang Department of Communicable Disease Control and Prevention, Department of Occupational Health and Environmental Health, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo 315010, China xugz@nbcdc.org.cn 
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Abstract:
      目的 估算新型冠状病毒肺炎病例密切接触者的感染率,评估不同暴露状况下新型冠状病毒肺炎的发病风险。方法 采用前瞻性研究的方法,对新型冠状病毒肺炎病例和无症状感染者的密切接触者进行持续隔离医学观察,收集流行病学、临床表现和实验室检测资料,估算不同暴露下的密切接触者感染率。结果 宁波市新型冠状病毒肺炎发病流行曲线呈现持续的人传人特征。共追踪调查了2 147名密切接触者,总感染率为6.15%,确诊病例、无症状感染者的密切接触者感染率分别为6.30%和4.11%,差异无统计学意义(P>0.05)。不同关系的密切接触者中,以朋友/香客(22.31%)、家庭成员(18.01%)、亲戚(4.73%)感染较高率,医务人员密切接触者未发生感染,各密切接触者人群感染率差异有统计学意义(P<0.005)。与病例同住(13.26%)、乘坐同一个交通工具(11.91%)、聚餐娱乐(7.18%)均是感染高危因素。医院诊疗环境下的交叉感染也不容忽视(1.94%)。潜伏期中位数为5 d。结论 新型冠状病毒肺炎病例密切接触者的感染率高,需严格按照密切接触者管理方案实施隔离医学观察措施。
English Abstract:
      Objective To estimate the infection rate of close contacts of COVID-19 cases, and to evaluate the risk of COVID-19 under different exposure conditions. Methods A prospective study was used to conduct continuous quarantine medical observations of close contacts of people infected with COVID-19, collect epidemiological, clinical manifestations, and laboratory test data to estimate the infection rate of close contacts under different exposures. Results The epidemiological curve of COVID-19 in Ningbo showed persistent human-to-human characteristics. A total of 2 147 close contacts were tracked and investigated. The total infection rate was 6.15%. The infection rates of confirmed cases and positive contacts were 6.30% and 4.11%, respectively. The difference was not statistically significant (P>0.05). Among close contacts of different relationships, friends/pilgrims (22.31%), family members (18.01%), and relatives (4.73%) have a higher infection rate, and close contacts of medical staff were not infected. Differences in infection rates among the close contacts were statistically significant (P<0.005). Living with the case (13.26%), taking the same transportation (11.91%), and dining together (7.18%) are high risk factors for infection. Cross-infection in the hospital should not be ignored (1.94%). The median of incubation period is 5 days. Conclusion The infection rate of close contacts of COVID-19 cases is high, and isolation medical observation measures should be implemented in strict accordance with the close contact management plan.
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