| 王冬萌,高文静,吕筠,余灿清,王胜锋,逄增昌,俞敏,汪华,吴先萍,董忠,吴凡,江国虹,王晓节,刘彧,邓健,陆林,曹卫华,李立明.中国成年双生子人群的冠心病遗传度估计[J].Chinese journal of Epidemiology,2020,41(5):700-704 |
| 中国成年双生子人群的冠心病遗传度估计 |
| Heritability of coronary heart disease, based on the data from the Chinese adult twins |
| Received:August 21, 2019 |
| DOI：10.3760/cma.j.cn112338-20190821-00612 |
| KeyWord: 冠心病 双生子研究 遗传度 |
| English Key Word: Coronary heart disease Twin study Heritability |
| FundProject:公益性行业科研专项（201502006，201002007）；国家自然科学基金（81711530051） |
| Author Name | Affiliation | E-mail | | Wang Dongmeng | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Gao Wenjing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Lyu Jun | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Yu Canqing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Wang Shengfeng | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Pang Zengchang | Qingdao Center for Disease Control and Prevention, Qingdao 266033, China | | | Yu Min | Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, China | | | Wang Hua | Jiangsu Center for Disease Control and Prevention, Nanjing 210009, China | | | Wu Xianping | Sichuan Center for Disease Control and Prevention, Chengdu 610041, China | | | Dong Zhong | Beijing Center for Disease Prevention and Control, Beijing 100013, China | | | Wu Fan | Shanghai Municipal Center for Disease Control & Prevention, Shanghai 200336, China | | | Jiang Guohong | Tianjin Centers for Diseases Control and Prevention, Tianjin 300011, China | | | Wang Xiaojie | Qinghai Center for Disease Control and Prevention, Xining 810007, China | | | Liu Yu | Heilongjiang Agricultural Center for Disease Control and Prevention, Harbin 150090, China | | | Deng Jian | Handan Center for Disease Control and Prevention, Handan 056001, China | | | Lu Lin | Yunnan Center for Disease Control and Prevention, Kunming 650034, China | | | Cao Weihua | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | caoweihua60@163.com | | Li Liming | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | |
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| Abstract: |
| 目的 分析中国成年双生子人群的冠心病遗传度。方法 利用中国双生子登记系统在11省、市募集的20 477对≥ 25岁同性别双生子，构建结构方程模型计算遗传度。结果 调整年龄、性别后，冠心病的遗传度为0.75（0.68~0.81）。亚组分析显示≥ 40岁组和女性人群中，冠心病患病主要受遗传因素的影响；而25~39岁组和男性的患病主要受环境因素的影响。结论 冠心病患病受遗传和环境因素的影响，且遗传度较高。 |
| English Abstract: |
| Objective To analyze the heritability of coronary heart disease (CHD) among the Chinese twin adults. Methods A total of 20 477 same-sex twin pairs aged 25 years and older from the Chinese National Twin Registry were interviewed. Structure equation model was used to estimate the heritability of CHD. Results After adjusting for age and gender, the overall heritability of CHD was 0.75(0.68-0.81). Stratified analyses showed that genetic factors play a more important role in CHD incidence in ≥ 40 years or female twins. While the development of CHD was mainly influenced by environmental factors in 25-39 years or male twins. Conclusion CHD is influenced by both genetic and environmental factors and the heritability is high. |
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