北京市成年人睡眠问题与血脂异常关系的研究

马爱娟; 方凯; 隗瑛琦; 姜博; 董晶; 谢晨; 董忠

Abstract

马爱娟,方凯,隗瑛琦,姜博,董晶,谢晨,董忠.北京市成年人睡眠问题与血脂异常关系的研究[J].Chinese journal of Epidemiology,2020,41(8):1250-1255

北京市成年人睡眠问题与血脂异常关系的研究

Study on the relationship between sleep-related problems and dyslipidemia among adults in Beijing

Received:December 24, 2019

DOI：10.3760/cma.j.cn112338-20191224-00909

KeyWord: 血脂异常高甘油三酯血症睡眠障碍打鼾

English Key Word: Dyslipidemia Hypertriglyceridemia Sleep disorder Snoring

FundProject:国家重点研发计划（2019YFC1605100）

Author Name	Affiliation	E-mail
Ma Aijuan	Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China
Fang Kai	Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China
Wei Yingqi	Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China
Jiang Bo	Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China
Dong Jing	Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China
Xie Chen	Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China
Dong Zhong	Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China	dongzhbjcdcmb@yeah.net

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Abstract:

目的探讨北京市成年人睡眠问题现状，及与血脂异常的关系，为血脂异常早期预防提供科学依据。方法 2017年8-12月采用多阶段分层整群随机抽样方法抽取北京市18～79岁常住居民13 188人作为调查对象，进行问卷调查、体格测量和实验室检查。采用调查问卷收集调查对象的人口学特征和睡眠情况等，测量身高体重，采集空腹静脉血，测定TC、HDL-C、LDL-C和TG。结果北京市成年人睡眠问题的比例为52.1%，且血脂异常患者（55.1%）高于血脂正常者（50.7%）。打鼾、入睡困难、夜间觉醒、早醒和服用安眠药的比例分别为30.1%、18.8%、24.6%、20.1%和3.0%。打鼾者高TC血症、高TG血症、高LDL-C血症患病率分别为7.5%、23.5%和6.6%，均高于不打鼾者（分别为5.7%、15.5%和4.9%）。夜间觉醒者TC平均水平和高TC血症患病率分别为4.74 mmo/L和7.5%，均明显高于无夜间觉醒者（4.66 mmol/L和5.8%）。在控制年龄、性别、吸烟、超重肥胖等潜在混杂因素后，打鼾与TC、TG和LDL-C水平呈正相关（P<0.05）；打鼾是血脂异常的危险因素（OR=1.248，P<0.05）。结论北京市成年人睡眠问题严重，主要睡眠问题是打鼾和夜间觉醒。打鼾与TC、TG和LDL-C水平呈正相关，是血脂异常的独立危险因素。

English Abstract:

Objective To investigate the status quo of sleelated problems and relationship with dyslipidemia among adults in Beijing. Methods From August to December 2017, 13 188 residents aged 18-79 years old were randomly selected as the subjects of this study, by stratified multi-stage cluster sampling method. Questionnaire, physical examination and laboratory testing were used in this study. The questionnaire included demographic characteristics and status quo of sleep. Height and weight were measured, with fasting venous blood collected to test the levels of TC, HDL-C, LDL-C and TG. Results In Beijing, 52.1% of the adults involved in this study were having sleep-related problems which appeared higher in patients with dyslipidemia (55.1%) than those without (50.7%). Rates of sleep-related problems as snoring, difficult to get into sleep, waking at night, waking early and taking sleeping pills were 30.1%, 18.8%, 24.6%, 20.1% and 3.0%, respectively. The prevalence rates of high TC, high TG and high LDL-C were 7.5%, 23.5% and 6.6%, respectively among subjects with snoring and as, 5.7%, 15.5% and 4.9%, respectively among those without. The average level of TC of people easy to wake at night was 4.74 mmol/L, higher than that of those without (4.66 mmol/L). The prevalence of high TC among those waking at night was 7.5%, higher than that of those without (5.8%). After controlling potential confounding factors as age, sex, smoking, overweight and obesity, snoring was significantly positively correlated to the levels of TC, TG and LDL-C (P<0.05) and presenting as risk factor for dyslipidemia, with OR=1.248 (P<0.05). Conclusion Sleep-related problems appeared serious, with snoring and waking at night the main ones among adults in Beijing. Snoring was significantly positively correlated with the levels of TC, TG and LDL-C and served an independent risk factor for dyslipidemia.

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