| 肖文佳,高强,金凯,宫霄欢,韩若冰,姜晨彦,蒋先进,金必红,方绮雯,潘浩,吴寰宇,孙晓冬.上海市一起潜伏期病例传播的新型冠状病毒肺炎聚集性疫情调查[J].Chinese journal of Epidemiology,2020,41(9):1401-1405 |
| 上海市一起潜伏期病例传播的新型冠状病毒肺炎聚集性疫情调查 |
| Investigation of an epidemic cluster caused by COVID-19 cases in incubation period in Shanghai |
| Received:March 02, 2020 |
| DOI：10.3760/cma.j.cn112338-20200302-00236 |
| KeyWord: 新型冠状病毒肺炎 聚集性疫情 潜伏期 传播 |
| English Key Word: COVID-19 Epidemic cluster Incubation period Transmission |
| FundProject:上海市新型冠状病毒感染的肺炎流行病学研究（20411950100） |
| Author Name | Affiliation | E-mail | | Xiao Wenjia | Institute of Infectious Disease Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Gao Qiang | Department of Vector Biological Control, Huangpu District Center for Disease Control and Prevention, Shanghai 200000, China | | | Jin Kai | Department of Acute Infectious Disease Prevention and Control, Baoshan District Center for Disease Control and Prevention, Shanghai 201900, China | | | Gong Xiaohuan | Institute of Infectious Disease Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Han Ruobing | Institute of Infectious Disease Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Jiang Chenyan | Institute of Infectious Disease Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Jiang Xianjin | Institute of Infectious Disease Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Jin Bihong | Institute of Infectious Disease Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Fang Qiwen | Institute of Infectious Disease Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Pan Hao | Institute of Infectious Disease Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Wu Huanyu | Institute of Infectious Disease Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Sun Xiaodong | Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | sunxiaodong_scdc@163.com |
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| Abstract: |
| 目的 对上海市一起由新型冠状病毒肺炎（COVID-19）病例在潜伏期传染的聚集性疫情开展流行病学调查，查明感染来源和病例传播链。方法 按照新型冠状病毒感染的肺炎防控方案（第三版）要求，2020年1月采用现场流行病学调查方法，对5例病例开展个案调查，采集鼻咽拭子和痰液等标本，采用real time RT-PCR检测新型冠状病毒核酸，追踪排查密切接触者并采取隔离医学观察，调查病例间的流行病学联系，分析传播链等，并及时落实相关防控措施。结果 病例一于2020年1月20日发病，有与COVID-19确诊病例共同环境的暴露史，2月1日确诊；病例二于1月22日发病，1月27日确诊；病例三于1月25日发病，1月30日确诊；病例四于1月20日发病，2月1日确诊；病例五于1月23日发病，1月31日确诊。5例病例中，除病例二死亡外，其余4例病例病情均得到有效控制。本起疫情中，排除其他的共同暴露因素后，1月19日病例一和病例二及病例三参加了6 h的聚会，病例一在潜伏期内可能造成病例二和病例三的感染，这是流行病学调查的关键节点。结论 COVID-19病例在潜伏内可能具有传染性，这对后面的疫情防控工作带来一定的警示和借鉴作用。 |
| English Abstract: |
| Objective To analyze the epidemiological characteristics of a cluster of 5 confirmed COVID-19 cases related with the transmission in incubation period of initial case, and find out the infection source and transmission chain. Methods According to “The Prevention and Control Protocol for Coronavirus Disease 2019 (Third Edition)” issued by the National Health Commission, a field epidemiological survey was conducted for the 5 cases in January 2020. Nasopharyngeal swabs and sputum samples were collected from them for the detection of 2019-nCoV by real time RT-PCR. Multi prevention and control measures were taken, such as tracking and screening close contacts, medical isolation observation, investigating the epidemiological link, analyzing transmission chain. Results Case 1, who had common environmental exposure with other COVID-19 cases, got sick on 20 January, 2020 and was confirmed on 1 February. Case 2 became symptomatic on 22 January and was confirmed on 27 January. Case 3 got sick on 25 January and was confirmed on 30 January. Case 4 had illness onset on 20 January and was confirmed on 1 February. Case 5 got sick on 23 January and was confirmed on 31 January. Among the 5 cases, case 2 died and the illness of other cases were effectively controlled. After exclusion of other common exposure factors, case 1 had a 6-hour meeting with case 2 and case 3 on 19 January. Case 2 and case 3 might be infected by case 1 during the incubation period. It is the key point for epidemiological investigation. Conclusion The epidemiological investigation indicates that the transmission might occur in the incubation period of COVID-19 case, close attention should be paid to it in future COVID-19 prevention and control. |
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