TNF-α及CCR5Δ32基因多态性与A（H1N1）pdm09相关性的Meta分析

陈涛; 肖梦; 禇堃; 唐晓君; 杨静; 舒跃龙

Abstract

陈涛,肖梦,禇堃,唐晓君,杨静,舒跃龙.TNF-α及CCR5Δ32基因多态性与A（H1N1）pdm09相关性的Meta分析[J].Chinese journal of Epidemiology,2020,41(11):1909-1914

TNF-α及CCR5Δ32基因多态性与A（H1N1）pdm09相关性的Meta分析

Meta-analysis on association between TNF-α and CCR5Δ32 gene polymorphisms and influenza A(H1N1)pdm09

Received:February 09, 2020

DOI：10.3760/cma.j.cn112338-20200209-00082

KeyWord: 肿瘤坏死因子-α CCR 基因多态流行性感冒

English Key Word: TNF-α CCR Gene polymorphism Influenza

FundProject:国家传染病重大专项（2018ZX10305409-004-002）

Author Name	Affiliation	E-mail
Chen Tao	Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention WHO Collaborating Center for Reference and Research on Influenza, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Xiao Meng	School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China
Chu Kun	School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China
Tang Xiaojun	School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China
Yang Jing	Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention WHO Collaborating Center for Reference and Research on Influenza, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Shu Yuelong	Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention WHO Collaborating Center for Reference and Research on Influenza, Chinese Center for Disease Control and Prevention, Beijing 102206, China School of Public Health(Shenzhen), Sun Yat-sen University, Guangzhou 510275, China	yshu@cnic.org.cn

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Abstract:

目的探讨肿瘤坏死因子-α（TNF-α）及CCR5Δ32基因多态性与A（H1N1）pdm09的相关性。方法全面检索PubMed、Cochrane Library、OVID、EBSCO、Web of Science于2019年2月7日及以前发表的相关文献，收集TNF-α及CCR5Δ32基因多态性与A（H1N1）pdm09相关的观察性研究，并按照NOS量表进行严格地质量评价，采用Revman 5.0和Stata 11.0软件进行Meta分析。结果经筛选，共8篇符合排除纳入标准的研究被纳入本次Meta分析，结果显示，TNF-α的基因多态性与A（H1N1）pdm09的发病风险可能具有相关性。rs361525位点携带A等位基因的患者A（H1N1）pdm09是G等位基因的2.25倍（A vs.G：OR=2.25，95% CI：1.09～4.65，P=0.03）；rs361525位点AA基因型的携带者感染A（H1N1）pdm09的可能性分别为GG基因型、AG+GG基因型携带者的4.34倍（95% CI：1.65～11.41，P=0.003）、4.38倍（95% CI：1.67～11.48，P=0.003）。rs361525位点的AA+AG基因型可能是人群感染A（H1N1）pdm09的危险因素（rs1800750：AA+AG vs.GG：OR=2.42，95% CI：1.24～4.71，P=0.01）。亚组分析的结果提示，rs361525位点的A等位基因、AA+AG基因型是高加索人种感染A（H1N1）pdm09的危险因素，AA基因型是墨西哥人种感染A（H1N1）pdm09的危险因素（P<0.05）。CCR5的基因多态性与A（H1N1）pdm09的严重程度均无统计学意义（P>0.05）。结论 TNF-α基因的rs361525位点具有等位基因A或者AA基因型，或rs1800750位点具有基因型AA+AG的人群可能更易感染A（H1N1）pdm09。

English Abstract:

Objective To investigate the associations between TNF-α and CCR5Δ32 gene polymorphisms and influenza A(H1N1)pdm09. Methods Studies in PubMed, Cochrane Library, OVID, EBSCO, Web of Science published before February 7, 2019 were retrieved comprehensively. Observational studies related to TNF-alpha and CCR5 gene polymorphisms and influenza A(H1N1) pdm09 were collected. A strict quality evaluation was carried out according to NOS scale. Meta-analysis was performed using software Revman 5.0 and Stata 11.0. Results After screening, a total of 8 studies were included in this Meta-analysis. The results showed that TNF-α gene polymorphism rs361525 might be associated with the risk of influenza A(H1N1)pdm09 virus infection (A vs. G: OR=2.25, 95%CI: 1.09-4.65, P=0.03; AA vs. GG: OR=4.34, 95%CI: 1.65-11.41, P=0.003; AA vs. AG+GG: OR=4.38, 95%CI: 1.67-11.48, P=0.003), similar trend also found in rs1800750 (AA+AG vs. GG: OR=2.42, 95%CI: 1.24-4.71, P=0.01). The results of subgroup analysis indicated that A allele and AA+AG genotypes of rs361525 were risk factors for influenza A(H1N1) pdm09 virus infection in Caucasians. AA genotype was a risk factor for influenza A(H1N1) pdm09 virus infection in Mexican (P<0.05). There was no significant difference in the genetic polymorphism of CCR5 and the severity of influenza A (H1N1) pdm09 virus indection (P>0.05). Conclusion People with allele A or genotype AA at rs361525, genotype AA+AG at rs1800750 of TNF-α gene might be more susceptible to influenza A(H1N1) pdm09.

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