| 赵培祯,程伟彬,唐卫明,郑和平,杨斌,王成.通过HIV/梅毒联合自我检测促进男男性行为人群进行梅毒检测的效果研究[J].Chinese journal of Epidemiology,2021,42(2):273-277 |
| 通过HIV/梅毒联合自我检测促进男男性行为人群进行梅毒检测的效果研究 |
| Evaluating the effectiveness of HIV/syphilis joint self-testing in promoting syphilis testing among men who have sex with men |
| Received:June 24, 2020 |
| DOI：10.3760/cma.j.cn112338-20200624-00880 |
| KeyWord: 男男性行为人群 梅毒 艾滋病病毒 自我检测 |
| English Key Word: Men who have sex with men Syphilis HIV Self-testing |
| FundProject:国家自然科学基金（81903371）；国家重点研发计划（2017YFE0103800）；国家科技重大专项（2018ZX10101-001-001-003）；广东省医学科学技术研究基金（A2018508，A2019524） |
| Author Name | Affiliation | E-mail | | Zhao Peizhen | Dermatology Hospital of Southern Medical University, Guangzhou 510095, China | | | Cheng Weibin | Dermatology Hospital of Southern Medical University, Guangzhou 510095, China | | | Tang Weiming | Dermatology Hospital of Southern Medical University, Guangzhou 510095, China
University of North Carolina at Chapel Hill, Project-China, Guangzhou 510095, China | | | Zheng Heping | Dermatology Hospital of Southern Medical University, Guangzhou 510095, China | | | Yang Bin | Dermatology Hospital of Southern Medical University, Guangzhou 510095, China | | | Wang Cheng | Dermatology Hospital of Southern Medical University, Guangzhou 510095, China | wangcheng090705@gmail.com |
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| Abstract: |
| 目的 评估HIV/梅毒联合自我检测（自检）在促进MSM梅毒检测方面的作用。方法 2019年7月通过淡蓝网（https：//www.danlan.org）招募研究对象，将符合纳入标准的研究对象按照1：1：1随机分为3组：HIV/梅毒联合自检组、彩票激励自检组和对照组。对HIV/梅毒联合自检组和彩票激励自检组通过网络邮寄HIV/梅毒联合自检试剂，对照组鼓励其到线下场所进行检测。1个月后随访研究对象，评估3个组梅毒检测比例的差别。结果 研究对象145人，其中对照组48人，HIV/梅毒联合自检组49人，彩票激励自检组48人。在随访期间HIV/梅毒联合自检组梅毒检测比例为74.4%（32/43），彩票激励自检组为70.0%（28/40），对照组为36.4%（16/44）。多因素logistic回归分析结果显示，HIV/梅毒联合自检组、彩票激励自检组在随访期间进行梅毒检测的比例分别是对照组的5.38（95%CI：2.06~14.04）倍和4.54（95%CI：1.75~11.74）倍。结论 HIV/梅毒联合自检、彩票激励自检均可以提高MSM的梅毒检测比例。HIV/梅毒联合自检具有推广的可行性。 |
| English Abstract: |
| Objective To evaluate the effectiveness of HIV/syphilis joint self-testing in promoting syphilis testing among men who have sex with men (MSM).Methods In July 2019, the research participants were recruited through the Danlan website (https://www.danlan.org). Participants who met the selection criteria, and were randomly assigned into one of the three study groups (1:1:1) including HIV/syphilis joint self-testing group and lottery incentive self-testing group and control group. Self-test reagents were mailed to HIV/syphilis joint self-testing group and lottery incentive self-testing group, and the subjects in control group were encouraged to go to offline locations for testing. One month later, follow-up was conducted to evaluate the differences in the testing rates of syphilis among the three groups.Results A total of 145 subjects were included in this study, including 48 in control group, 49 in HIV/syphilis joint self-testing group and 48 in lottery incentive self-testing group. During the follow-up period, the self-testing rate of syphilis was 74.4% (32/43) in HIV/syphilis joint self-testing group, 70.0% (28/40) in lottery incentive self-testing group and 36.4% (16/44) in control group. Multivariate logistic analysis revealed that the proportions of syphilis testing in HIV/syphilis joint self-testing group and lottery incentive self-testing group were 5.38 (95%CI:2.06-14.04) times and 4.54 (95% CI:1.75-11.74) times higher than that in control group during the follow-up period.Conclusions HIV/syphilis joint self-testing and lottery-incentives-prompted self-testing significantly increased the testing rate of syphilis in MSM, respectively. HIV/syphilis joint self-testing is feasible for promotion. |
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