| 乔世杰,周素娟,徐璐璐,陈潇潇,许圆圆,沈伟伟,刘星,林海江,何纳.台州市2017-2018年新报告HIV/AIDS巨细胞病毒血症现患率及影响因素研究[J].Chinese journal of Epidemiology,2021,42(2):316-320 |
| 台州市2017-2018年新报告HIV/AIDS巨细胞病毒血症现患率及影响因素研究 |
| Prevalence and correlates of plasma cytomegalovirus viremia among newly reported HIV/AIDS patients in Taizhou city, 2017-2018 |
| Received:April 20, 2020 |
| DOI：10.3760/cma.j.cn112338-20200420-00601 |
| KeyWord: 艾滋病病毒/艾滋病 巨细胞病毒 病毒血症 现患率 影响因素 |
| English Key Word: HIV/AIDS Cytomegalovirus Viremia Prevalence Related factors |
| FundProject:国家科技重大专项（2018ZX10721102-004） |
| Author Name | Affiliation | E-mail | | Qiao Shijie | Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China | | | Zhou Sujuan | Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China | | | Xu Lulu | Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China | | | Chen Xiaoxiao | Taizhou City Center for Disease Control and Prevention, Taizhou 318000, China | | | Xu Yuanyuan | Taizhou City Center for Disease Control and Prevention, Taizhou 318000, China | | | Shen Weiwei | Taizhou City Center for Disease Control and Prevention, Taizhou 318000, China | | | Liu Xing | Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China | | | Lin Haijiang | Taizhou City Center for Disease Control and Prevention, Taizhou 318000, China | 84800166@qq.com | | He Na | Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China | nhe@fudan.edu.cn |
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| Abstract: |
| 目的 了解2017-2018年台州市新报告且未接受抗病毒治疗（ART）的HIV/AIDS血浆巨细胞病毒血症现患率及其影响因素。方法 收集台州市新报告且未接受ART的成年HIV/AIDS血浆样本，提取核酸后采用荧光定量PCR检测巨细胞病毒DNA水平，采用单因素与多因素logistic回归分析其影响因素。结果 研究对象612例HIV/AIDS中，男性480例（78.4%），年龄>60岁125例（20.4%），同性性传播者177例（28.9%），异性性传播者430例（70.3%）。巨细胞病毒血症现患率为13.4%（82/612）。多因素logistic回归分析结果显示，CD4+T淋巴细胞计数（CD4）≤ 200个/μl者现患巨细胞病毒血症的风险显著高于CD4>500个/μl者（OR=5.10，95%CI：1.74~14.96，P=0.003）；82例现患巨细胞病毒血症者的血浆巨细胞病毒DNA载量（log10）中位数为1.57（P25，P75：1.04，2.13），CD4 ≤ 200个/μl者的巨细胞病毒载量最高（P<0.01）。结论 2017-2018年台州市新报告未接受ART的HIV/AIDS中，巨细胞病毒血症现患率与免疫缺陷状态显著关联，巨细胞病毒血症对HIV/AIDS病程的影响有待进一步研究。 |
| English Abstract: |
| Objective To study the prevalence and correlates of plasma cytomegalovirus (CMV) viremia among newly reported antiretroviral therapy (ART)-naive HIV/AIDS patients in Taizhou during 2017-2018.Methods CMV DNA was measured in plasma specimens of newly reported ART-naive HIV/AIDS patients by quantitative PCR. Both univariable and multivariable logistic regression analyses were carried out to evaluate CMV viremia correlations among the individuals.Results Of 612 HIV/AIDS patients, 480 (78.4%) were male, 125 (20.4%) were over 60 years old, 177 (28.9%) were infected via homosexual transmission, and 430 (70.3%) via heterosexual transmission. The prevalence of CMV viremia among HIV/AIDS patients was 13.4% (82/612). Multivariable logistic regression analysis showed that the risk of CMV viremia in CD4+ lymphocyte cells counts (CD4+) ≤ 200 cells/μl group was higher than CD4 counts >500 cells/μl (OR=5.10, 95%CI:1.74-14.96, P=0.003); The median CMV DNA level (log10) of 82 viremic patients was 1.57 (P25,P75:1.04,2.13); Viremic patients with CD4 counts ≤ 200 cells/μl had the highest CMV viral load (P<0.01).Conclusions Among ART-naive HIV/AIDS patients, the prevalence of CMV viremia was significantly associated with immunodeficiency status. Further research is needed to evaluate the association between CMV viremia and the course of HIV infection. |
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