| 戚家豪,魏俊妮,张振君,东靓,张丽,董丽,毛盈颖,雷立健,胡晓琴,白文启.他汀类药物与结直肠癌相关性的Meta分析[J].Chinese journal of Epidemiology,2021,42(2):343-350 |
| 他汀类药物与结直肠癌相关性的Meta分析 |
| A Meta-analysis on association between statins and colorectal cancer |
| Received:January 19, 2020 |
| DOI：10.3760/cma.j.cn112338-20200119-00045 |
| KeyWord: 他汀类药物 结直肠肿瘤 Meta分析 |
| English Key Word: Statins Colorectal neoplasm Meta-analysis |
| FundProject:国家自然科学基金（81803326，81602917）；山西省应用基础研究项目（201801D221265）；山西省研究生教育改革研究课题（2020YJJG134） |
| Author Name | Affiliation | E-mail | | Qi Jiahao | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | | | Wei Junni | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | | | Zhang Zhenjun | Division of Medical Affairs, Shanxi Cancer Hospital, Taiyuan 030001, China | | | Dong Liang | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | | | Zhang Li | Department of Gastroenterology, Taiyuan Central Hospital, Taiyuan 030001, China | | | Dong Li | Department of Gastroenterology, Taiyuan Central Hospital, Taiyuan 030001, China | | | Mao Yingying | Department of Epidemiology, School of Public Health, Zhejiang Traditional Chinese Medical University, Hangzhou 310053, China | | | Lei Lijian | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | | | Hu Xiaoqin | Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China | huxiaoqin.love@163.com | | Bai Wenqi | Department of Colorectal and Anal Surgery, Shanxi Cancer Hospital, Taiyuan 030001, China | 326498302@qq.com |
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| Abstract: |
| 目的 探讨他汀类药物与结直肠癌间的关系，为结直肠癌的预防提供循证医学依据。方法 系统检索中国知网（CNKI）、万方数据知识服务平台（Wanfang data）、PubMed和Cochrane Library数据库中从2000年1月至2020年1月所有他汀类药物与结直肠癌研究的文献，按照纳入排除标准选择文献，并用纽卡斯尔-渥太华量表和Jadad评分进行评价。采用Revman 5.0和Stata 12.1软件进行Meta分析。结果 共纳入31篇文献，162万受试者参与。病例对照研究（RR=0.93，95%CI：0.88~0.98）、队列研究（RR=0.75，95%CI：0.63~0.88）和随机对照试验研究（RR=0.79，95%CI：0.65~0.97）均显示他汀类药物对结直肠癌具有一定保护作用；服用他汀类药物<5年（RR=0.86，95%CI：0.76~0.96）、日均服用剂量≥ 34 mg （RR=0.81，95%CI：0.66~0.98）和服用脂溶性他汀类药物（RR=0.86，95%CI：0.74~0.99）会降低结直肠癌发生风险。结论 他汀类药物对结直肠癌有一定的预防作用。 |
| English Abstract: |
| Objective To explore the association between statins and colorectal cancer and provide evidence for the prevention of colorectal cancer.Methods Literatures about statins and colorectal cancer published from January 2000 to January 2020 were retrieved from CNKI, Wanfang data, PubMed and Cochrane Library database. The literatures which met the inclusion criteria were collected, and the Newcastle-Ottawa Scale and Jadad score were used to assess the studies. Meta-analysis was performed with statistical software Revman 5.0 and Stata 12.1.Results A total of 31 studies, involving more than 1.62 million subjects, were included in the analysis. The case-control study (RR=0.93, 95%CI:0.88-0.98), the cohort study (RR=0.75, 95%CI:0.63-0.88) and the randomized controlled trial (RR=0.79, 95%CI:0.65-0.97) showed moderate protective effect of statins. Using statin <5 years (RR=0.86, 95%CI:0.76-0.96), average daily dosage ≥ 34 mg (RR=0.81, 95%CI:0.66-0.98) and lipid-soluble statins (RR=0.86, 95%CI:0.74-0.99) also had preventive effect on colorectal cancer; while lovastatin (RR=1.07, 95%CI:1.00-1.14) increased the risk of colorectal cancer.Conclusion Statins have protective effect on colorectal cancer. |
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