甘油三酯、空腹血糖及甘油三酯葡萄糖乘积指数与高血压发病风险的前瞻性队列研究

王若楠; 张德生; 白朝; 尹春; 张瑞; 杨景丽; 包凯芳; 黄文雅; 黄佩瑶; 柳念; 王玉峰; 程宁; 白亚娜

Abstract

王若楠,张德生,白朝,尹春,张瑞,杨景丽,包凯芳,黄文雅,黄佩瑶,柳念,王玉峰,程宁,白亚娜.甘油三酯、空腹血糖及甘油三酯葡萄糖乘积指数与高血压发病风险的前瞻性队列研究[J].Chinese journal of Epidemiology,2021,42(3):482-487

甘油三酯、空腹血糖及甘油三酯葡萄糖乘积指数与高血压发病风险的前瞻性队列研究

Prospective cohort study of relationship of triglyceride, fasting blood-glucose and triglyceride glucose product index with risk of hypertension

Received:April 01, 2020

DOI：10.3760/cma.j.cn112338-20200401-00491

KeyWord: 高血压甘油三酯空腹血糖甘油三酯葡萄糖乘积指数

English Key Word: Hypertension Triglyceride Fasting blood-glucose Triglyceride glucose product index

FundProject:兰州大学“一带一路”专项（2018ldbrzd008）；美国国立卫生研究院（1R01ES029082）

Author Name	Affiliation	E-mail
Wang Ruonan	Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China
Zhang Desheng	Workers'Hospital of Jinchuan Group, Jinchang 737100, China
Bai Zhao	Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China
Yin Chun	Workers'Hospital of Jinchuan Group, Jinchang 737100, China
Zhang Rui	Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China
Yang Jingli	Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China
Bao Kaifang	Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China
Huang Wenya	Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China
Huang Peiyao	Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China
Liu Nian	Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China
Wang Yufeng	Workers'Hospital of Jinchuan Group, Jinchang 737100, China
Cheng Ning	School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
Bai Yana	Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China	baiyana@lzu.edu.cn

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Abstract:

目的探讨TG、FPG及TG葡萄糖乘积指数（TyG）与高血压发病间的关系，为人群高血压的防治提供基础数据。方法以金昌队列中符合研究标准的23 581人作为研究对象，运用Cox比例风险模型研究TG、FPG及TyG与高血压发病风险间的关系，并按性别进行分层分析。结果在调整混杂因素后，与正常TG组相比，总人群中TG边缘升高组和升高组的HR值（95%CI）分别为1.16（1.01~1.34）和1.49（1.30~1.70），男性中分别为1.13（1.01~1.27）和1.17（1.06~1.30），女性中分别为1.05（0.88~1.26）和1.06（0.88~1.28）；与正常FPG组相比，总人群中空腹血糖受损组的HR值（95%CI）为1.29（1.13~1.48），男性中为1.26（1.08~1.48），女性中为1.59（1.14~2.21）；以最低四分位数组为参照，总人群中TyG的最高四分位数组的HR值（95%CI）为1.73（1.45~2.07），男性中为1.32（1.14~1.53），女性中为1.87（1.37~2.54）。TG、FPG与高血压发病风险间呈非线性的剂量反应关系，TyG与高血压发病风险线性相关。结论较高的TG、FPG、TyG是高血压发病的独立危险因素，TG、FPG及TyG较高的人群为高血压的高危人群，在高血压防治中应予以重视。

English Abstract:

Objective To investigate the relationship of triglyceride (TG), fasting blood glucose (FPG) and triglyceride glucose product index (TyG) with the incidence of hypertension, and provide basic data for the prevention and treatment of hypertension in the population. Methods A total of 23 581 individuals who met the research criteria in Jinchang cohort were selected as the research subjects, the Cox proportional hazard model was used to analyze the relationship of TG, FPG, and TyG with the risk of hypertension. A stratified analysis was conducted by sex. Results After adjusting for confounding factors, compared with the normal TG group, the HR(95%CI) of the elevated TG margin group and the elevated group were 1.16 (1.01-1.34) and 1.49 (1.30-1.70), respectively in the total population. Among men, they were 1.13 (1.01-1.27) and 1.17 (1.06-1.30), and among women, they were 1.05 (0.88-1.26) and 1.06 (0.88-1.28). Compared with the normal FPG group, the HR (95%CI) of the FPG-impaired group were 1.29 (1.13-1.48) in the total population, 1.26 (1.08-1.48) in men and 1.59 (1.14-2.21) in women. Taking the lowest quartile array as a reference, the HR (95%CI) of the highest quartile array of TyG was 1.73 (1.45-2.07) in the total population, 1.32 (1.14-1.53) in men and 1.87 (1.37-2.54) in women. TG, FPG had a nonlinear dose-response relationship with the risk of hypertension, while TyG had a linear correlation with the risk of hypertension. Conclusions Higher TG, FPG, and TyG levels are independent risk factors for the incidence of hypertension. People with higher TG, FPG and TyG are at high risk for hypertension, to which close attention should be paid in the prevention and treatment of hypertension.

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