中国国家出生队列孤独症谱系障碍亚队列建设概况

杜江波; 丁叶; 黄磊; 蒋杨倩; 孟庆霞; 宋词; 吕红; 刘晓宇; 徐菠; 林苑; 马红霞; 靳光付; 李红; 凌秀凤; 柯晓燕; 沈洪兵; 胡志斌

Abstract

杜江波,丁叶,黄磊,蒋杨倩,孟庆霞,宋词,吕红,刘晓宇,徐菠,林苑,马红霞,靳光付,李红,凌秀凤,柯晓燕,沈洪兵,胡志斌.中国国家出生队列孤独症谱系障碍亚队列建设概况[J].Chinese journal of Epidemiology,2021,42(4):591-596

中国国家出生队列孤独症谱系障碍亚队列建设概况

The Autism Spectrum Disorder Cohort-the sub-cohort of China National Birth Cohort

Received:December 11, 2020

DOI：10.3760/cma.j.cn112338-20201211-01405

KeyWord: 孤独症队列研究辅助生殖自然妊娠

English Key Word: Autism spectrum disorder Cohort study Assisted reproductive technology Spontaneous pregnancy

FundProject:国家重点研发计划（2018YFC1004200，2016YFC1000200）

Author Name	Affiliation	E-mail
Du Jiangbo	Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Ding Ye	Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Huang Lei	Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Jiang Yangqian	Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Meng Qingxia	Reproductive and Genetic Center, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215002, China
Song Ci	Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Lyu Hong	Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Liu Xiaoyu	Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Xu Bo	Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Lin Yuan	Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China State Key Laboratory of Reproductive Medicine, Center for Global Health, Nanjing Medical University, Nanjing 211166, China
Ma Hongxia	Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China State Key Laboratory of Reproductive Medicine, Center for Global Health, Nanjing Medical University, Nanjing 211166, China
Jin Guangfu	Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China State Key Laboratory of Reproductive Medicine, Center for Global Health, Nanjing Medical University, Nanjing 211166, China
Li Hong	Reproductive and Genetic Center, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215002, China
Ling Xiufeng	Reproductive Medical Center, Nanjing Medical University Affiliated Maternity and Child Health Hospital, Nanjing 210011, China
Ke Xiaoyan	Child Mental Health Research Center, Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China
Shen Hongbing	Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China State Key Laboratory of Reproductive Medicine, Center for Global Health, Nanjing Medical University, Nanjing 211166, China
Hu Zhibin	Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China State Key Laboratory of Reproductive Medicine, Center for Global Health, Nanjing Medical University, Nanjing 211166, China	zhibin_hu@njmu.edu.cn

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Abstract:

孤独症谱系障碍作为儿童神经发育障碍的代表性疾病，发病率呈现不断上升的趋势，给家庭和社会带来巨大压力和经济负担，探讨其病因及发病机制意义重大。本研究依托中国国家出生队列开展孤独症谱系障碍亚队列建设，并利用该出生队列采用的辅助生殖和自然妊娠同期纳入并随访的平行设计，评价辅助生殖技术对子代神经行为发育的影响，并结合队列采集的多种母体孕期和子代生命早期临床及行为相关信息，综合探究孤独症谱系障碍的发病危险因素。本文将从研究目标、内容、初步进展、优势与不足及进一步展望对该亚队列进行简要介绍，重点展现本研究的总体设计和现阶段进展。

English Abstract:

Autism spectrum disorder (ASD), a representative disease of children's neurodevelopmental disorders, brings huge pressure and financial burden to families and society. It is of great significance to explore its etiology and pathogenesis. Therefore, we established an ASD Cohort based on the existing China National Birth Cohort (CNBC), which applied parallel design to recruit and follow up families who achieved pregnancy after receiving assisted reproductive technologies (ART) and families with spontaneous conception. The main aims of this study are to compare the incidence of ASD among children born after ART with those born under spontaneous pregnancy, and to evaluate the impact of ART on the neurobehavioral development of offspring. Additionally, with a variety of clinical and behavioral related information collected during pregnancy and at early life of offspring, we are able to investigate the risk factors associated with ASD comprehensively. This article briefly introduces the objectives, contents, preliminary progress, strength and limitations, as well as further prospects of the ASD cohort study, mainly focusing on the overall design and current progress.

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