宁波市2019年健康人群百日咳血清流行病学调查

赵薛飞; 叶硕; 马瑞; 董红军; 方挺; 许国章

Abstract

赵薛飞,叶硕,马瑞,董红军,方挺,许国章.宁波市2019年健康人群百日咳血清流行病学调查[J].Chinese journal of Epidemiology,2021,42(4):638-642

宁波市2019年健康人群百日咳血清流行病学调查

Seroepidemiology of pertussis in healthy population in Ningbo, 2019

Received:June 29, 2020

DOI：10.3760/cma.j.cn112338-20200629-00894

KeyWord: 百日咳血清流行病学感染

English Key Word: Pertussis Seroepidemiology Infection

FundProject:宁波市医疗卫生品牌学科（PPXK2018-10）；浙江省医学重点学科（07-013）

Author Name	Affiliation	E-mail
Zhao Xuefei	Ningbo Prefectural Center for Disease Control and Prevention, Ningbo 315010, China
Ye Shuo	Ningbo Prefectural Center for Disease Control and Prevention, Ningbo 315010, China
Ma Rui	Ningbo Prefectural Center for Disease Control and Prevention, Ningbo 315010, China
Dong Hongjun	Ningbo Prefectural Center for Disease Control and Prevention, Ningbo 315010, China
Fang Ting	Ningbo Prefectural Center for Disease Control and Prevention, Ningbo 315010, China
Xu Guozhang	Ningbo Prefectural Center for Disease Control and Prevention, Ningbo 315010, China	xugz@nbcdc.org.cn

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Abstract:

目的了解宁波市健康人群百日咳感染血清流行病学特征，评估人群百日咳实际感染水平。方法采用横断面调查设计，分层随机抽取宁波市3个区（县）9个年龄组共1 206名健康居民纳入研究，采集调查对象血清并用ELISA法定量检测血清百日咳毒素IgG（PT-IgG）抗体。结果调查对象PT-IgG抗体阳性率为0.91%（95%CI：0.45%~1.63%），抗体几何平均滴度（GMT）为3.10（95%CI：2.86~3.36）IU/ml。9个年龄组人群PT-IgG抗体阳性率在0.00%~1.68%之间，GMT在2.08~5.28 IU/ml之间。≥5岁人群百日咳评估感染率为4 572.81/10万（95%CI：1 807.30/10万~9 348.12/10万），感染率高峰出现在5~岁组和≥50岁组，分别为9 301.62/10万（95%CI：1 121.77/10万~33 154.68/10万）和8 967.02/10万（95%CI：1 059.45/10万~31 845.94/10万）。结论 2019年宁波市人群百日咳实际感染率较高。由于疫苗诱导产生的抗体并不持久，宁波市青少年和成年人已成为百日咳感染重点人群。建议强化百日咳监测能力，完善疫苗免疫策略。

English Abstract:

Objective To understand the seroepidemiological characteristics of pertussis in healthy population in Ningbo, and estimate the overall incidence of pertussis. Methods A cross-sectional survey method was used in this study. A total of 1 206 healthy residents in 9 age groups were stratified randomly selected from 3 counties of Ningbo. Serum samples were collected from the subjects, and the pertussis toxin immunoglobulin G antibody (PT-IgG) levels were measured quantitatively by enzyme-linked immunosorbent assay (ELISA). Results The mean PT-IgG seropositive rate in the subjects was 0.91% (95%CI:0.45%-1.63%) with a geometric mean titer (GMT) of 3.10 (95%CI:2.86-3.36) IU/ml. The seropositive rates ranged from 0.00% to 1.68%, and the GMTs ranged from 2.08 IU/ml to 5.28 IU/ml in 9 age groups. The incidence rate of pertussis was estimated to be 4 572.81 per 100 000 in age group ≥ 5 years (95%CI:1 807.30 per 100 000-9 348.12 per 100 000), and the peak of estimated incidence rates were found in age group 5-years (9 301.62 per 100 000, 95%CI:1 121.77 per 100 000-33 154.68 per 100 000) and age group ≥ 50 years old (8 967.02 per 100 000, 95%CI:1 059.45 per 100 000-31 845.94 per 100 000). Conclusions The actual incidence of pertussis was high in Ningbo in 2019. As a result of waning immunity after vaccination, pertussis can occur in adolescents and adults. The pertussis surveillance should be strengthened and the pertussis vaccination strategy should be improved.

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