| 陈松建,高文静,吕筠,余灿清,王胜锋,黄涛,孙点剑一,廖春晓,逄增昌,俞敏,汪华,吴先萍,董忠,吴凡,江国虹,王晓节,刘彧,邓健,陆林,曹卫华,李立明.体力活动对2型糖尿病遗传效应的修饰作用——中国双生子队列研究[J].Chinese journal of Epidemiology,2021,42(7):1167-1173 |
| 体力活动对2型糖尿病遗传效应的修饰作用——中国双生子队列研究 |
| Modification of physical activity on genetic effects of type 2 diabetes mellitus: a twin pairs cohort study in China |
| Received:October 23, 2020 |
| DOI：10.3760/cma.j.cn112338-20201023-01265 |
| KeyWord: 糖尿病,2型 双生子研究 基因环境交互作用 |
| English Key Word: Diabetes mellitus, type 2 Twin study Gene-environment interaction |
| FundProject:公益性行业科研专项（201502006，201002007）；国家自然科学基金（81711530051） |
| Author Name | Affiliation | E-mail | | Chen Songjian | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Gao Wenjing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | pkuepigwj@126.com | | Lyu Jun | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Yu Canqing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Wang Shengfeng | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Huang Tao | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Sun Dianjianyi | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Liao Chunxiao | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Pang Zengchang | Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China | | | Yu Min | Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China | | | Wang Hua | Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210008, China | | | Wu Xianping | Sichuan Center for Disease Control and Prevention, Chengdu 610041, China | | | Dong Zhong | Beijing Center for Disease Prevention and Control, Beijing 100013, China | | | Wu Fan | Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Jiang Guohong | Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China | | | Wang Xiaojie | Qinghai Center for Disease Prevention and Control, Xining 810007, China | | | Liu Yu | Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150030, China | | | Deng Jian | Handan Center for Disease Control and Prevention, Handan 056001, China | | | Lu Lin | Yunnan Center for Disease Control and Prevention, Kunming 650037, China | | | Cao Weihua | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Li Liming | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | |
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| Abstract: |
| 目的 探究体力活动对2型糖尿病遗传效应的修饰作用。方法 利用中国双生子登记系统在11省/市募集的12 107对≥ 30岁同性别双生子，拟合单变量交互作用模型计算体力活动对2型糖尿病遗传效应的修饰作用。结果 调整年龄、性别后，2型糖尿病的遗传度为0.56（0.31~0.84）。体力活动达标可降低2型糖尿病的遗传效应。体力活动达标双生子2型糖尿病的遗传度为0.46（0.06~0.88），低于相同模型中体力活动未达标双生子2型糖尿病的遗传度[0.68（0.36~0.94）]。结论 2型糖尿病属于中度遗传疾病，体力活动可修饰2型糖尿病的遗传效应。 |
| English Abstract: |
| Objective To explore the modification effect of physical activity on the genetic effects of type 2 diabetes mellitus (T2DM). Methods The univariate moderation model was fitted to calculate the modifying effect of physical activity on the genetic effects of T2DM based on the data of 12 107 pairs of same gender twins aged 30 years and older enrolled by the Chinese National Twin Registry in 11 provinces/cities in China. Results After adjusting for age and gender, the heritability of T2DM was 0.56 (0.31-0.84). Qualified physical activity could attenuate the genetic effects of T2DM. The heritability of T2DM in twin pairs with qualified physical activity was 0.46 (0.06-0.88), which was lower than that in twin pairs without qualified physical activity during the same model[0.68(0.36-0.94)]. Conclusion T2DM is a moderate genetic disease, physical activity can modify the genetic effects of T2DM. |
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