| 赵雪,吕静静,颜丙玉,冯艺,窦璇,刘甲野,徐爱强,张丽.农村社区非活动性HBsAg携带者HBV再激活发生率及特征分析[J].Chinese journal of Epidemiology,2021,42(9):1553-1558 |
| 农村社区非活动性HBsAg携带者HBV再激活发生率及特征分析 |
| Rates and characteristics for hepatitis B reactivation of inactive hepatitis B carriers in rural communities |
| Received:March 19, 2021 |
| DOI：10.3760/cma.j.cn112338-20210319-00220 |
| KeyWord: 慢性乙型肝炎 乙型肝炎表面抗原 非活动性乙型肝炎表面抗原携带者 乙型肝炎病毒再激活 |
| English Key Word: Chronic hepatitis B HBsAg Inactive HBsAg carriers Hepatitis B virus reactivation |
| FundProject:国家科技重大专项（2018ZX10721202）；国家自然科学基金（81803299）；山东省自然科学基金（ZR2019PH046）；山东省医药卫生科技发展计划（2015WS0285） |
| Author Name | Affiliation | E-mail | | Zhao Xue | School of Public Health, Cheeloo College of Medicine, Shandong University, Ji'nan 250012, China | | | Lyu Jingjing | Department of Immunization Programme, Shandong Center for Disease Control and Prevention, Ji'nan 250014, China | | | Yan Bingyu | Department of Immunization Programme, Shandong Center for Disease Control and Prevention, Ji'nan 250014, China | | | Feng Yi | Department of Immunization Programme, Shandong Center for Disease Control and Prevention, Ji'nan 250014, China | | | Dou Xuan | School of Public Health, Cheeloo College of Medicine, Shandong University, Ji'nan 250012, China | | | Liu Jiaye | The Third People's Hospital of Shenzhen, Shenzhen 518112, China | | | Xu Aiqiang | School of Public Health, Cheeloo College of Medicine, Shandong University, Ji'nan 250012, China | aqxuepi@163.com | | Zhang Li | Department of Immunization Programme, Shandong Center for Disease Control and Prevention, Ji'nan 250014, China | zl9127@163.com |
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| Abstract: |
| 目的 了解农村社区非活动性HBsAg携带者（IHC）中HBV再激活的发生强度和特征。方法 分别于2018、2020年对济南市章丘区农村社区人群体检中发现的IHC进行随访调查，比较2次随访结果，分析基于社区人群的IHC的HBV再激活发生率和分布特征。结果 424名IHC完成了2次随访，发现HBV再激活者47例，累积再激活发生率为11.08%，发病密度为5.46/100人年；多因素分析显示，性别、年龄、吸烟、饮酒及肝病家族史和慢性病史与HBV再激活不相关（P>0.05），基线HBV DNA载量与再激活相关（P<0.05），当HBV DNA基线水平≥ 1 000 IU/ml时，累积再激活发生率可达18.92%。发生再激活后，ALT平均水平较基线升高且异常率增加，再激活者肝功能趋于异常。4例（8.51%）再激活者发生肝炎，其中1例（2.13%）为黄疸型肝炎。结论 济南市农村社区IHC中HBV再激活发生率较高；大部分再激活者处于无症状或轻度再激活状态；应加强对IHC的随访并密切监测其ALT和HBV DNA水平变化，并适时采取正规的治疗措施。 |
| English Abstract: |
| Objective To analyze the intensity and epidemiological characteristics of hepatitis B virus (HBV) reactivation among inactive HBsAg carriers (IHC) of rural areas in Ji'nan. Methods In 2018 and 2020, follow-up investigations were conducted on IHC identified in the population physical examination in Zhangqiu district of Ji'nan. The results of the two follow-up visits were compared to analyze the incidence and distribution characteristics of HBV reactivation in IHC at the community level. Results A total of 424 IHC completed two follow-up visits, and 47 cases of HBV reactivation were found, the cumulative reactivation rate was 11.08%, and the incidence density was 5.46/100 person-years. Multivariate analysis showed that gender, age, smoking, drinking, family history of liver disease and chronic diseases were not associated with HBV reactivation (P>0.05), and baseline HBV DNA load was associated with reactivation (P<0.05), in the HBV DNA level ≥ 1 000 IU/ml group, the reactivation rate could reach 18.92%. After reactivation, the mean level of ALT increased from baseline and the abnormal rate increased, liver function tended to be abnormal in reactivated patients. 4 (8.51%) reactivators had hepatitis, and 1 (2.13%) had jaundice hepatitis.Conclusions The incidence of HBV reactivation was higher among IHC in rural communities in Ji'nan. Most of the reactivators were asymptomatic or mildly reactivated. Follow-up of inactive HBsAg patients should be strengthened and changes in ALT and HBV DNA levels should be closely monitored. |
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