| 聂佳,陈璐,余灿清,郭彧,裴培,陈君石,陈铮鸣,吕筠,李立明,代表中国慢性病前瞻性研究项目协作组.中国成年人饮茶与死亡风险的前瞻性关联研究[J].Chinese journal of Epidemiology,2022,43(2):145-153 |
| 中国成年人饮茶与死亡风险的前瞻性关联研究 |
| Association between tea consumption and all-cause mortality in Chinese adults |
| Received:December 01, 2020 |
| DOI：10.3760/cma.j.cn112338-20201201-01369 |
| KeyWord: 饮茶 死亡风险 前瞻性研究 中国人 |
| English Key Word: Tea consumption Mortality Prospective study Chinese |
| FundProject:国家自然科学基金（81941018）；国家重点研发计划（2016YFC0900500）；中国香港Kadoorie Charitable基金；英国Wellcome Trust（212946/Z/18/Z，202922/Z/16/Z，104085/Z/14/Z，088158/Z/09/Z） |
| Author Name | Affiliation | E-mail | | Nie Jia | Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Peking University Center for Public Health and Epidemic Preparedness and Response/Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing 100191, China | | | Chen Lu | Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Peking University Center for Public Health and Epidemic Preparedness and Response/Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing 100191, China | | | Yu Canqing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Peking University Center for Public Health and Epidemic Preparedness and Response/Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing 100191, China | | | Guo Yu | Fuwai Hospital Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Beijing 100037, China | | | Pei Pei | Chinese Academy of Medical Sciences, Beijing 100730, China | | | Chen Junshi | China National Center for Food Safety Risk Assessment, Beijing 100022, China | | | Chen Zhengming | Nuffield Department of Population Health, Center for Clinical and Epidemiological Studies/Population Health Research Unit, Medical Research Council, University of Oxford, Oxford OX3 7LF, UK | | | Lyu Jun | Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Peking University Center for Public Health and Epidemic Preparedness and Response/Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing 100191, China | lvjun@bjmu.edu.cn | | Li Liming | Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Peking University Center for Public Health and Epidemic Preparedness and Response/Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing 100191, China | | | for the China Kadoorie Biobank Collaborative Group | | |
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| Abstract: |
| 目的 分析中国成年人饮茶与全因死亡和死因别死亡风险间的关联。方法 本研究分析基于中国慢性病前瞻性研究项目。饮茶信息为基线自报。死亡信息主要通过链接死亡监测系统获取。使用Cox比例风险回归模型计算风险比（HR）及其95%CI。结果 纳入分析的438 443例研究对象随访11.1年共发生死亡34 661例。与从不饮茶者相比，当前非每日饮茶者和每日饮茶者全因死亡HR值（95%CI）依次为0.89（0.86~0.91）和0.92（0.88~0.95）。分性别分析显示，饮茶对全因死亡风险的保护作用主要见于男性（交互P<0.05）。与从不饮茶者相比，当前每日饮茶者死于缺血性心脏病、缺血性脑卒中、出血性脑卒中、恶性肿瘤、呼吸系统疾病及其他死因的HR值（95%CI）依次为0.83（0.76~0.92）、0.82（0.69~0.97）、0.86（0.78~0.94）、1.03（0.97~1.09）、1.00（0.87~1.16）、0.84（0.78~0.90）。在不吸烟且不过量饮酒者中，每日饮茶与恶性肿瘤死亡风险间不存在有统计学显著性的关联，但在吸烟或过量饮酒者中，每日饮茶者死于恶性肿瘤的风险增加（交互P<0.001）。结论 饮茶者的全因死亡和部分死因别死亡的风险降低；但饮茶与恶性肿瘤的死亡风险不存在关联，反而在同时伴有吸烟或过量饮酒习惯者中表现出增加的死亡风险。 |
| English Abstract: |
| Objective To investigate the association between tea consumption and the risk of all-cause and cause-specific mortality among Chinese adults. Methods This study was based on China Kadoorie Biobank (CKB). Tea consumption information was self-reported by participants at baseline. Death was mainly identified by linkage to the death registry system. Cox proportional hazard regression models estimated HR and 95%CI. Results With a median follow-up of 11.1 years, there were 34 661 deaths in 438 443 participants. Compared with those who never drink tea, all-cause mortality HR(95%CI) were 0.89(0.86-0.91) and 0.92(0.88-0.95) for non-daily tea drinkers and daily tea drinkers, respectively. A statistically significant difference was found in the association of tea consumption and the risk of all-cause mortality between men and women(interaction P<0.05). The protective effect was mainly seen in men. Compared with those who never drink tea, daily tea drinkers had a reduced risk of death from ischemic heart disease, ischemic stroke, hemorrhagic stroke, cancer, respiration diseases and other causes of death, and the corresponding HR(95%CI) were 0.83(0.76-0.92), 0.82(0.69-0.97), 0.86(0.78-0.94), 1.03(0.97-1.09), 1.00(0.87-1.16), 0.84(0.78-0.90). Among never smokers and non-excessive drinkers, there was no statistically significant association between daily tea drinking and the risk of death from cancer. While smokers and excessive drinkers had an increased risk of death from cancer (interaction P<0.001).Conclusions Tea consumers had reduced risks of all-cause mortality and partial cause-specific mortality, but not for the risk of death from cancer. On the contrary, daily tea drinkers with smoking habits and excessive alcohol drinking had an increased risk of death from cancer. |
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