| 奚玉娥,高文静,吕筠,余灿清,王胜锋,黄涛,孙点剑一,廖春晓,庞元捷,逄增昌,俞敏,汪华,吴先萍,董忠,吴凡,江国虹,王晓节,刘彧,邓健,陆林,曹卫华,李立明.探究中国双生子人群中的冠心病遗传-生活方式交互作用[J].Chinese journal of Epidemiology,2022,43(5):649-654 |
| 探究中国双生子人群中的冠心病遗传-生活方式交互作用 |
| Gene-lifestyle interaction on coronary heart disease in adult twins of China |
| Received:July 07, 2021 |
| DOI：10.3760/cma.j.cn112338-20210707-00530 |
| KeyWord: 冠心病 生活方式 遗传-环境交互作用 双生子研究 |
| English Key Word: Coronary heart disease Lifestyle Gene-environment interaction Twin study |
| FundProject:国家自然科学基金(81973126,81711530051);公益性行业科研专项(201502006,201002007) |
| Author Name | Affiliation | E-mail | | Xi Yu'e | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Gao Wenjing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Lyu Jun | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Yu Canqing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Wang Shengfeng | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Huang Tao | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Sun Dianjianyi | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Liao Chunxiao | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Pang Yuanjie | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Pang Zengchang | Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China | | | Yu Min | Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China | | | Wang Hua | Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | | | Wu Xianping | Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610041, China | | | Dong Zhong | Beijing Center for Disease Prevention and Control, Beijing 100013, China | | | Wu Fan | Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Jiang Guohong | Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China | | | Wang Xiaojie | Qinghai Center for Diseases Prevention and Control, Xining 810007, China | | | Liu Yu | Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150090, China | | | Deng Jian | Handan Center for Disease Control and Prevention, Handan 056001, China | | | Lu Lin | Yunnan Center for Disease Control and Prevention, Kunming 650034, China | | | Cao Weihua | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | caoweihua60@163.com | | Li Liming | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | |
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| Abstract: |
| 目的 分析中国成年双生子人群的冠心病遗传-生活方式交互作用。方法 利用中国双生子登记系统募集的研究对象，构建单变量交互作用模型，通过分析生活方式对冠心病遗传效应的效应修饰作用，探索冠心病的遗传-生活方式交互作用。结果 本研究共纳入20 477对≥25岁的同性别双生子，含395例冠心病患者，其中66对双生子均患冠心病。调整年龄和性别后，当前吸烟、当前饮酒、体力活动和蔬果摄入等生活方式对冠心病的遗传效应均没有修饰作用（均P>0.05）。结论 在本研究的中国成年双生子人群中未发现冠心病的遗传-生活方式交互作用。 |
| English Abstract: |
| Objective To explore the gene-lifestyle interaction on coronary heart disease (CHD) in adult twins of China. Methods Participants were selected from twin pairs registered in the Chinese National Twin Registry (CNTR). Univariate interaction model was used to estimate the interaction, via exploring the moderation effect of lifestyle on the genetic variance of CHD. Results A total of 20 477 same-sex twin pairs aged ≥25 years were recruited, including 395 CHD cases, and 66 twin pairs both had CHD. After adjustment for age and sex, no moderation effects of lifestyles, including current smoking, current drinking, physical activity, intake of vegetable and fruit, on the genetic variance of CHD were found (P>0.05), suggesting no significant interactions.Conclusion There was no evidence suggesting statistically significant gene-lifestyle interaction on CHD in adult twins of China. |
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