| 鲁欣然,赖雪峰,孙凤,詹思延,王胜锋.加强药物基因组学研究报告规范（STROPS）及解读[J].Chinese journal of Epidemiology,2022,43(5):747-754 |
| 加强药物基因组学研究报告规范（STROPS）及解读 |
| Strengthening the Reporting of Pharmacogenetic Studies (STROPS) guideline |
| Received:April 02, 2021 |
| DOI：10.3760/cma.j.cn112338-20210402-00276 |
| KeyWord: 药物基因组学研究报告规范 条目清单 解读 |
| English Key Word: Strengthening the Reporting of Pharmacogenetic Studies Guideline Checklist Interpretation |
| FundProject:国家自然科学基金(81502884);国家重点研发计划(2018YFC1311704) |
| Author Name | Affiliation | E-mail | | Lu Xinran | Department of Epidemiology and Biostatistics School of Public Health, Peking University, Beijing 100191, China | | | Lai Xuefeng | Department of Epidemiology and Biostatistics School of Public Health, Peking University, Beijing 100191, China | | | Sun Feng | Department of Epidemiology and Biostatistics School of Public Health, Peking University, Beijing 100191, China | | | Zhan Siyan | Department of Epidemiology and Biostatistics School of Public Health, Peking University, Beijing 100191, China
Center for Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China | siyan-zhan@bjmu.edu.cn;王胜锋，wangshengfeng@bjmu.edu.cn | | Wang Shengfeng | Department of Epidemiology and Biostatistics School of Public Health, Peking University, Beijing 100191, China | wangshengfeng@bjmu.edu.cn |
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| Abstract: |
| 药物基因组学研究旨在探究遗传变异与药物的疗效和不良反应之间的关联，对样本量有很高的要求。为有效进行Meta分析以探究药物遗传关联，亟需提高药物基因组学研究报告质量。2020年制定的加强药物基因组学研究报告规范（Strengthening the Reporting of Pharmacogenetic Studies，STROPS）在STREGA规范（Strengthening the Reporting of Genetic Association Studies）的基础上进行补充和修改，为药物基因组学研究报告提供专门的指导。本文将重点介绍STROPS并对部分条目进行解读，同时给出实例以便理解和应用。 |
| English Abstract: |
| Pharmacogenetic studies are designed to investigate the associations between genetic variation and treatment response for a particular drug in terms of both efficacy and adverse events and have high sample size requirements. To improve the quality of pharmacogenetic studies and facilitate the Meta-analyses to investigate statistically significant associations, Strengthening the Reporting of Pharmacogenetic Studies (STROPS) guideline was developed in 2020 based on the Strengthening the Reporting of Genetic Association Studies (STREGA) statement. The objective of this article is to present a brief introduction to the STROPS guideline and an interpretation of the key points in some items with examples for the better understanding and application. |
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