诊断试验准确性比较研究的偏倚评估工具——QUADAS-C

杨秋玉; 陆瑶; 谢欣玲; 赖鸿皓; 田晨; 牛猛; 田金徽; 李霓; 李江; 葛龙

Abstract

杨秋玉,陆瑶,谢欣玲,赖鸿皓,田晨,牛猛,田金徽,李霓,李江,葛龙.诊断试验准确性比较研究的偏倚评估工具——QUADAS-C[J].Chinese journal of Epidemiology,2022,43(6):938-944

诊断试验准确性比较研究的偏倚评估工具——QUADAS-C

QUADAS-C—A tool for assessing risk of bias regarding Quality Assessment of Diagnostic Accuracy Studies-Comparative

Received:November 01, 2021

DOI：10.3760/cma.j.cn112338-20211101-00841

KeyWord: 诊断试验准确性比较研究偏倚风险系统评价

English Key Word: Comparative diagnostic test accuracy study Risk of bias Systematic review

FundProject:北京市科技新星计划（Z201100006820070）；甘肃省科技计划（20CX4ZA027，20CX9ZA112）

Author Name	Affiliation	E-mail
Yang Qiuyu	Evidence Based Nursing Centre, School of Nursing, Lanzhou University, Lanzhou 730000, China
Lu Yao	Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou 730000, China Department of Social Science and Health Management, School of Public Health, Lanzhou University, Lanzhou 730000, China
Xie Xinling	The Second School of Clinical Medicine of Lanzhou University, Lanzhou 730000, China
Lai Honghao	Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou 730000, China Department of Social Science and Health Management, School of Public Health, Lanzhou University, Lanzhou 730000, China
Tian Chen	Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou 730000, China Department of Social Science and Health Management, School of Public Health, Lanzhou University, Lanzhou 730000, China
Niu Meng	Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China
Tian Jinhui	Evidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, China
Li Ni	National Cancer Center/National Cancer Clinical Medical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Li Jiang	National Cancer Center/National Cancer Clinical Medical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China	lij@cicams.ac.cn
Ge Long	Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou 730000, China Department of Social Science and Health Management, School of Public Health, Lanzhou University, Lanzhou 730000, China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, China	gelong2009@163.com

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Abstract:

本文介绍了诊断试验准确性比较研究的偏倚评估工具（QUADAS-C）的主要内容，阐述了QUADAS-C与QUADAS-2的联系与区别，同时介绍了如何将QUADAS-C与QUADAS-2结合使用及如何呈现评价结果。QUADAS-C在QUADAS-2的基础上，共扩展14个标志性问题，形成4个关键领域（病例选择、待评价试验、金标准、病例流程和待评价试验与金标准之间的时间间隔）。与QUADAS-2不同的是，QUADAS-C各领域第一个标志性问题的回答均需结合QUADAS-2的评价结果；此外，QUADAS-C仅评价原始研究的偏倚风险而不包含适用性评价。完成QUADAS-C评价最终得出原始研究每个领域偏倚风险为“低”“高”或“不清楚”的结果。

English Abstract:

This paper introduced the Quality Assessment of Diagnostic Accuracy Studies-Comparative (QUADAS-C), illustrated the comparison with the QUADAS-2, and using QUADAS-C together with QUADAS-2 to present QUADAS-C results through systematic reviews. Like the domain for QUADAS-2, QUADAS-C retained four domains, including patient selection, index test, reference standard, flow, and timing, and comprised additional questions for each QUADAS-2 part. Unlike the QUADAS-2 tool, the starting question of each domain for QUADAS-C was designed to summarize the risk of biased information captured by QUADAS-2. QUADAS-C only dealt with the risk of bias but did not include the part of concerns regarding applicability. The answers to signaling questions for each domain of QUADAS-C would lead to a 'low''high' or 'unclear' risk of biased judgment for the original study.

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