| 陈卿,周文正,周妮娅,杨桓,王艺蒙,张海燕,李秋红,王念蓉,陈红燕,敖琳,刘晋祎,周紫垣,张华,周玮,漆洪波,曹佳.重庆市孕前生殖健康与出生结局队列：设计简介与建设概况[J].Chinese journal of Epidemiology,2022,43(7):1134-1139 |
| 重庆市孕前生殖健康与出生结局队列：设计简介与建设概况 |
| Preconception reproductive health and birth outcome cohort in Chongqing: the cohort profile |
| Received:February 19, 2022 |
| DOI：10.3760/cma.j.cn112338-20220219-00134 |
| KeyWord: 出生队列 暴露组学 自然妊娠 孕前因素 精液 |
| English Key Word: Birth cohort Exposomics Spontaneous pregnancy Preconception Semen |
| FundProject:国家自然科学基金重点项目(82130097);重庆市技术创新与应用示范专项社会民生类重点研发项目(cstc2018jscx-mszdX0021) |
| Author Name | Affiliation | E-mail | | Chen Qing | Institute of Toxicology, College of Military Preventive Medicine, Third Military Medical University/Army Medical University, Chongqing 400038, China | | | Zhou Wenzheng | Quality Management Department, Women and Children's Hospital of Chongqing Medical University, Chongqing 401120, China | | | Zhou Niya | Institute of Toxicology, College of Military Preventive Medicine, Third Military Medical University/Army Medical University, Chongqing 400038, China | | | Yang Huan | Institute of Toxicology, College of Military Preventive Medicine, Third Military Medical University/Army Medical University, Chongqing 400038, China | | | Wang Yimeng | Institute of Toxicology, College of Military Preventive Medicine, Third Military Medical University/Army Medical University, Chongqing 400038, China | | | Zhang Haiyan | Department of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, Chongqing 401120, China | | | Li Qiuhong | Clinical Laboratory Department, Women and Children's Hospital of Chongqing Medical University, Chongqing 401120, China | | | Wang Nianrong | Department of Pediatrics, Women and Children Hospital of Chongqing Medical University, Chongqing 401120, China | | | Chen Hongyan | Quality Management Department, Women and Children's Hospital of Chongqing Medical University, Chongqing 401120, China | | | Ao Lin | Institute of Toxicology, College of Military Preventive Medicine, Third Military Medical University/Army Medical University, Chongqing 400038, China | | | Liu Jinyi | Institute of Toxicology, College of Military Preventive Medicine, Third Military Medical University/Army Medical University, Chongqing 400038, China | | | Zhou Ziyuan | Department of Environmental Health, College of Military Preventive Medicine, Third Military Medical University/Army Medical University, Chongqing 400038, China | | | Zhang Hua | Administration Office, Chongqing Health Center for Women and Children, Chongqing 401120, China | | | Zhou Wei | Administration Office, Chongqing Health Center for Women and Children, Chongqing 401120, China | | | Qi Hongbo | Administration Office, Chongqing Health Center for Women and Children, Chongqing 401120, China | qihongbo728@163.com | | Cao Jia | Institute of Toxicology, College of Military Preventive Medicine, Third Military Medical University/Army Medical University, Chongqing 400038, China | caojia1962@126.com;漆洪波，qihongbo728@163.com |
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| Abstract: |
| 出生队列是研究生命早期暴露对健康结局影响的重要工具，但目前缺乏有力支撑孕前暴露特别是父系暴露对生殖健康和妊娠结局影响研究的大型队列平台。重庆市孕前生殖健康与出生结局队列研究是起始于孕前阶段，同等关注男女双方的环境、心理、行为等暴露因素对生殖健康和不良妊娠结局影响的前瞻性队列研究。项目于2019年正式启动，计划招募有生育意愿的育龄夫妇20 800人。通过随访，调查志愿者2年内是否自然受孕。对进入妊娠期的女性志愿者，在孕早、中、晚期进一步随访，并对分娩的子代随访至2岁，监测早产、低出生体重、出生缺陷、神经功能发育障碍等结局发生情况。各阶段分别采集相应的数据信息和生物样本，包括精液、外周血、尿液、胎盘、脐带、脐带血、口腔拭子等。截至2022年1月，已纳入志愿者8 698人，分布于重庆市所有38个区/县。本队列建设目标是成为涵盖父母双方的前瞻性大样本孕前出生队列，将以独特的设计和更加全面的视角阐明全生育周期特别是孕前期暴露因素对生殖健康和不良出生结局的影响及机制。 |
| English Abstract: |
| Birth cohort is an important platform to study the effect of early-life exposure on health outcome, but large cohorts to investigate the effect of preconception exposure, especially paternal exposure, on reproductive health and birth outcome are limited. The Preconception Reproductive Health and Birth Outcome Cohort (PREBIC) is a prospective birth cohort study which pays equal attention to the contribution of environmental, psychological, behavioral as well as other factors to reproductive health and adverse birth outcomes in both men and women in Chongqing, China. PREBIC started in 2019 and plans to recruit 20 800 reproductive-age couples with child-bearing willingness. Followed up was conducted to understand the conception status of the women within two years. Women in pregnancy would be visited at first, second, third trimesters and after delivery. The offspring would be monitored until 2 years old to understand the incidences of preterm birth, low birth weight, birth defects, neurodevelopmental disorders and other outcomes. Related information and biospecimen collections (including semen, peripheral blood, urine, placenta, umbilical cord, cord blood and oral swab) were scheduled in each period. By January 2022, PREBIC had recruited 8 698 participants from all 38 districts in Chongqing. The goal of PREBIC is to establish one of the largest prospective preconception birth cohorts covering both men and women, which might provide a unique insight to understand the effects of the full reproductive cycle on reproductive health and adverse outcomes, with especial emphasis on preconception exposures. |
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