2011-2020年宁波市鄞州区成年人类风湿关节炎发病的流行病学研究

曾雪扬; 刘志科; 沈鹏; 孙烨祥; 刘栩; 詹思延; 林鸿波; 孙凤

Abstract

曾雪扬,刘志科,沈鹏,孙烨祥,刘栩,詹思延,林鸿波,孙凤.2011-2020年宁波市鄞州区成年人类风湿关节炎发病的流行病学研究[J].Chinese journal of Epidemiology,2022,43(8):1288-1295

2011-2020年宁波市鄞州区成年人类风湿关节炎发病的流行病学研究

Epidemiological study on the incidence of rheumatoid arthritis in adults in Yinzhou district, Ningbo city from 2011-2020

Received:December 01, 2021

DOI：10.3760/cma.j.cn112338-20211201-00941

KeyWord: 类风湿关节炎发病密度流行病学研究区域医疗健康大数据

English Key Word: Rheumatoid arthritis Incidence density Epidemiologic study Regional health big data

FundProject:国家自然科学基金（91846303）；中国中医药循证医学中心业务研究室主任专项（2020YJSZX-2）

Author Name	Affiliation	E-mail
Zeng Xueyang	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Liu Zhike	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Shen Peng	Yinzhou District Center for Disease Control and Prevention, Ningbo 315199, China
Sun Yexiang	Yinzhou District Center for Disease Control and Prevention, Ningbo 315199, China
Liu Xu	Department of Rheumatology, Peking University People's Hospital, Beijing 100034, China
Zhan Siyan	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Lin Hongbo	Yinzhou District Center for Disease Control and Prevention, Ningbo 315199, China	lin73160@163.com
Sun Feng	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China	sunfeng@bjmu.edu.cn

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Abstract:

目的描述2011-2020年宁波市鄞州区成年人类风湿关节炎（RA）发病趋势及其在不同年龄、性别人群中的发病差异。方法利用鄞州区域健康信息平台（YRHIP）进行回顾性队列研究，以YRHIP中研究对象排除既往病史后被首次确诊RA者作为新发病例。采用Poisson分布估算RA发病密度及其95%CI。结果 2011-2020年鄞州区≥18周岁常住人口共1 280 012人，其中女性665 361人（51.98%）；总随访人年7 198 513.61，中位随访人年5.41（P₂₅=3.50，P₇₅=8.32）；新发RA病例2 350人，其中女性1 460人（62.13%）。总研究人群10年发病密度32.65/10万人年（95%CI：31.34/10万人年~33.99/10万人年），女性发病密度为39.17/10万人年（95%CI：37.19/10万人年~41.24/10万人年），男性发病密度为25.64/10万人年（95%CI：23.98/10万人年~27.38/10万人年），性别差异有统计学意义（P<0.001）；30岁及以上各年龄组的发病风险均高于18~29岁组（均P<0.001），且18~79岁时，年龄越大，发病风险越高，≥80岁时发病风险略有下降；2013年发病密度最低15.30/10万人年（95%CI：12.62/10万人年~18.38/10万人年），2016年发病密度最高为56.70/10万人年（95%CI：51.24/10万人年~62.58/10万人年），不同年份发病差异有统计学意义（P=0.004）。结论 2011-2020年宁波市鄞州区成年人RA发病密度呈现先增长后下降，又趋于平缓的趋势，不同年份、年龄、性别人群的发病密度存在差异。

English Abstract:

Objective To describe the distribution and trend of rheumatoid arthritis (RA) in adults in the Yinzhou district from 2011 to 2020 and compare the incidence differences in different ages and genders. Methods Using the retrospective cohort design, we collected all new cases diagnosed with RA between 2011 to 2020 from the Yinzhou Regional Health Information Platform (YRHIP). Poisson distribution was used to estimate RA's incidence density and 95%CI. Results From 2011 to 2020, 1 280 012 permanent residents in Yinzhou district were included, of which 665 361 were female (51.98%). The total follow-up person-years were 7 198 513.61, and the median follow-up person-year was 5.41 years (P₂₅=3.50, P₇₅=8.32). During the study period, there were 2 350 new cases of RA, of which 1 460 were female (62.13%). The 10-year incidence density of the population was 32.65/100 000 person-years (95%CI:31.34/100 000 person-years-33.99/100 000 person-years), that of females was 39.17/100 000 person-years (95%CI:37.19/100 000 person-years-41.24/100 000 person-years), and that of the male was 25.64/100 000 person-years (95%CI:23.98/100 000 person-years-27.38/100 000 person-years), the gender difference was statistically significant (P<0.001). The incidence risk in all age groups above 30 years old was higher than that in the 18-29 years old group (P<0.001), and the incidence risk increased with age from 18-79 years old while decreased slightly with age ≥ 80 years old. The lowest incidence density was 15.30/100 000 person-years in 2013 (95%CI:12.62/100 000 person-years-18.38/100 000 person- years), and the highest was 56.70/100 000 person-years in 2016 (95%CI:51.24/100 000 person- years-62.58/100 000 person-years), with statistically significant differences among different years (P=0.004). Conclusions From 2011 to 2020, the incidence density of RA in adults in Yinzhou district first increased, then decreased, and tended to stabilize. There were differences in incidence density in different years, ages, and genders.

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