青岛市成年人体质指数与冠心病发病关联的前瞻性研究

宋佳慧; 潘驰; 李斐斐; 薛晓嘉; 郭彧; 裴培; 田小草; 汪韶洁; 高汝钦; 逄增昌; 陈铮鸣; 李立明

Abstract

宋佳慧,潘驰,李斐斐,薛晓嘉,郭彧,裴培,田小草,汪韶洁,高汝钦,逄增昌,陈铮鸣,李立明.青岛市成年人体质指数与冠心病发病关联的前瞻性研究[J].Chinese journal of Epidemiology,2022,43(9):1357-1363

青岛市成年人体质指数与冠心病发病关联的前瞻性研究

Association between body mass index and coronary heart disease in Qingdao: a prospective study

Received:October 12, 2021

DOI：10.3760/cma.j.cn112338-20211012-00789

KeyWord: 体质指数冠心病前瞻性研究

English Key Word: Body mass index Coronary heart disease Prospective study

FundProject:国家重点研发计划精准医学研究重点专项(2016YFC0900500,2016YFC0900501,2016YFC0900504);中国香港Kadoorie Charitable基金;英国Wellcome Trust (202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z);青岛市医疗卫生优秀人才培养项目

Author Name	Affiliation	E-mail
Song Jiahui	Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao 266071, China
Pan Chi	Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao 266071, China
Li Feifei	Department of Non-communicable Disease Control and Prevention, Qingdao Prefectural Center for Disease Control and Prevention, Qingdao 266033, China
Xue Xiaojia	Department of Non-communicable Disease Control and Prevention, Qingdao Prefectural Center for Disease Control and Prevention, Qingdao 266033, China
Guo Yu	Chinese Academy of Medical Sciences, Beijing 100730, China
Pei Pei	Chinese Academy of Medical Sciences, Beijing 100730, China
Tian Xiaocao	Department of Non-communicable Disease Control and Prevention, Qingdao Prefectural Center for Disease Control and Prevention, Qingdao 266033, China Qingdao Institute of Preventive Medicine, Qingdao 266033, China	txc_2006911@126.com
Wang Shaojie	Department of Non-communicable Disease Control and Prevention, Qingdao Prefectural Center for Disease Control and Prevention, Qingdao 266033, China
Gao Ruqin	Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao 266071, China Qingdao Prefectural Center for Disease Control and Prevention, Qingdao 266033, China	gaoruqin@sohu.com
Pang Zengchang	Department of Non-communicable Disease Control and Prevention, Qingdao Prefectural Center for Disease Control and Prevention, Qingdao 266033, China
Chen Zhengming	Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK
Li Liming	School of Public Health, Peking University, Beijng 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China

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Abstract:

目的分析青岛市成年人体质指数（BMI）与冠心病发病之间的关联。方法研究对象来自中国慢性病前瞻性研究青岛市项目点，共纳入33 355名30~79岁研究对象，采用Cox比例风险回归模型，分析BMI与冠心病发病的关联。结果调查对象平均随访9.2人年，共监测缺血性心脏病（IHD）2 712例，主要冠心病事件（MCE）420例。多因素Cox回归分析显示，与体重正常或过低的人群相比，超重和肥胖人群IHD及MCE的风险增加，超重组发病风险分别增加了41%和87%，HR值（95%CI）分别为1.41（1.27~1.56）和1.87（1.43~2.44），肥胖组分别增加了91%和143%，HR值（95%CI）分别为1.91（1.72~2.13）和2.43（1.82~3.24）。结论超重和肥胖会增加IHD和MCE的发病风险。

English Abstract:

Objective To analyze the association between body mass index (BMI) and coronary heart disease.Methods The data for the present study were from the prospective cohort study of China Kadoorie Biobank (CKB) in Qingdao,a total of 33 355 participants aged 30-79 years were included in the study.Cox regression analyses were performed to evaluate the association between BMI and coronary heart disease.Results During the follow-up for an average 9.2 years,a total of 2 712 cases of ischemic heart disease (IHD) and 420 cases of major coronary events (MCE) were found.Multivariate Cox regression analysis showed that,compared with participants with normal BMI,the participants who were overweight had a 41% and 87% higher risk of IHD and MCE,the adjusted HR were 1.41(95%CI:1.27-1.56) and 1.87(95%CI:1.43-2.44),respectively.The participants who were obesity had 91% and 143% higher risk of IHD and MCE,the adjusted HR were 1.91(95%CI:1.72-2.13) and 2.43(95%CI:1.82-3.24),respectively.Conclusion Overweight and obesity might increase the risk for IHD and MCE.

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