成都市男男性行为人群3种类型HIV暴露前预防用药使用意愿及影响因素分析

李志康; 朱洋; 杨潇; 陈晓婷; 顾菁; 郝元涛; 曹望楠; 李菁华

Abstract

李志康,朱洋,杨潇,陈晓婷,顾菁,郝元涛,曹望楠,李菁华.成都市男男性行为人群3种类型HIV暴露前预防用药使用意愿及影响因素分析[J].Chinese journal of Epidemiology,2022,43(10):1658-1665

成都市男男性行为人群3种类型HIV暴露前预防用药使用意愿及影响因素分析

Willingness to use the three types of pre-exposure prophylaxis and associated factors among men who have sex with men in Chengdu

Received:May 01, 2022

DOI：10.3760/cma.j.cn112338-20220501-00367

KeyWord: 暴露前预防用药男男性行为人群艾滋病污名

English Key Word: Pre-exposure prophylaxis Men who have sex with men HIV Stigma

FundProject:国家自然科学基金（81803334）；国家科技重大专项（2018ZX10715004）

Author Name	Affiliation	E-mail
Li Zhikang	School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Zhu Yang	School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Yang Xiao	School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Chen Xiaoting	School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Gu Jing	School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Hao Yuantao	School of Public Health, Peking University, Beijing 100191, China
Cao Wangnan	School of Public Health, Peking University, Beijing 100191, China	lijinghua3@mail.sysu.edu.cn
Li Jinghua	School of Public Health, Sun Yat-sen University, Guangzhou 510080, China	wangnancao@bjmu.edu.cn

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Abstract:

目的调查成都市MSM对3种类型HIV暴露前预防用药（PrEP）的使用意愿及影响因素。方法 2021年11月至2022年1月，依靠成都同乐健康咨询服务中心招募793名研究对象。收集社会人口学特征、最近6个月性行为发生情况、PrEP污名、HIV预期污名、MSM内化污名和3种类型PrEP的使用意愿。采用单因素和多因素logistic回归模型分析3种类型PrEP使用意愿的影响因素。结果在793名研究对象中，按需口服药物的使用意愿较高（68.3%）。较高文化程度和多性伴均会促进口服类PrEP的使用意愿，较高文化程度[与初中及以下相比，高中/中专（aOR=2.43，95%CI：1.13~5.21）、大专（aOR=2.67，95%CI：1.27~5.61）、大学本科（aOR=3.21，95%CI：1.52~6.74）、硕士研究生及以上（aOR=3.77，95%CI：1.54~9.26）]、多性伴（aOR=1.54，95%CI：1.12~2.11）均与每天口服1粒药物呈正相关。较高的HIV预期污名对3种类型PrEP使用意愿均呈正相关：每天口服1粒药物（aOR=1.07，95%CI：1.02~1.12）、按需口服药物（aOR=1.09，95%CI：1.03~1.15）、每隔8周注射1次药物（aOR=1.06，95%CI：1.01~1.11）。结论成都市MSM的PrEP整体使用意愿较高，推广PrEP有较高的可行性。未来应加强对该人群HIV和PrEP相关知识的宣传教育，提高认知水平，引导MSM树立正确的PrEP使用动机。

English Abstract:

Objective To investigate the willingness to use three types of pre-exposure prophylaxis (PrEP) and its associated factors among MSM in Chengdu.Methods A total of 793 MSM were recruited through Chengdu Tongle Health Consultation Service Centre between November 2021 to January 2022. Data were collected, including demographic characteristics, sexual behaviors in the last six months, PrEP-related stigma, HIV anticipated stigma, MSM internalized stigma, and willingness to use three types of PrEP. Univariate and multivariate logistic regression models were conducted to investigate the associated factors of willingness in using the three types of PrEP.Results Among 793 participants, willingness to take on-demand PrEP was higher (68.3%). Higher education and multiple sexual partners increased the willingness to use oral PrEP, higher education[compared with junior high school or below, high school or technical secondary school (aOR=2.43, 95%CI:1.13-5.21), junior college (aOR=2.67, 95%CI:1.27-5.61), bachelor degree (aOR=3.21, 95%CI:1.52-6.74), master degree or above (aOR=3.77, 95%CI:1.54-9.26)], multiple sexual partners (aOR=1.54, 95%CI:1.12-2.11) were positively associated with daily oral PrEP. HIV anticipated stigma was positively associated with the willingness in using all three types of PrEP:daily oral PrEP (aOR=1.07, 95%CI:1.02-1.12), on-demand PrEP (aOR=1.09, 95%CI:1.03-1.15), and injectable PrEP every 8 week (aOR=1.06, 95%CI:1.01-1.11).Conclusions The overall willingness in using PrEP in MSM in Chengdu is relatively high, and the promotion of PrEP is highly feasible. In the future, we should continue to promote publicity and education on HIV and PrEP-related knowledge in this population, improve the cognitive level, and guide MSM to establish the correct motivation for PrEP use.

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