| 窦媛燕,杜江波,蒋杨倩,宋词,马红霞,林苑,沈洪兵,胡志斌.中国国家出生队列研究的理念与实践[J].Chinese journal of Epidemiology,2023,44(1):54-59 |
| 中国国家出生队列研究的理念与实践 |
| Principles and practice of China National Birth Cohort |
| Received:October 25, 2022 |
| DOI：10.3760/cma.j.cn112338-20221025-00909 |
| KeyWord: 中国国家出生队列 多中心 辅助生殖技术 |
| English Key Word: China National Birth Cohort Multicenter Assisted reproductive technology |
| FundProject:国家重点研发计划“生育健康及妇女儿童健康保障”重点专项（2021YFC2700600）；国家重点研发计划“生殖健康及重大出生缺陷防控研究”重点专项（2016YFC1000200） |
| Author Name | Affiliation | E-mail | | Dou Yuanyan | Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China | | | Du Jiangbo | Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China
State Key Laboratory of Reproductive Medicine (Suzhou Municipal Hospital), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215002, China | | | Jiang Yangqian | State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China
Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Song Ci | Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Ma Hongxia | Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China
State Key Laboratory of Reproductive Medicine (Suzhou Municipal Hospital), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215002, China | | | Lin Yuan | State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China
Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China
State Key Laboratory of Reproductive Medicine (Suzhou Municipal Hospital), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215002, China | | | Shen Hongbing | Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China | | | Hu Zhibin | Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China
State Key Laboratory of Reproductive Medicine (Suzhou Municipal Hospital), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215002, China | zhibin_hu@njmu.edu.cn |
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| Abstract: |
| 出生队列研究在探讨生命早期暴露对子代远期健康的影响中发挥重要作用。随着育龄人口生殖健康问题的凸显，辅助生殖技术被广泛应用于临床。而关于辅助生殖技术对母婴健康的远期影响尚未得到充分研究。2016年，以家庭为单位，同步招募辅助受孕家庭和自然受孕家庭的多中心前瞻性的中国国家出生队列（CNBC）研究正式启动。截至2021年6月30日，已累计在全国招募7.2万个家庭，包括辅助生殖家庭3.9万个和自然妊娠家庭3.3万个，本队列以面对面随访的形式在辅助生殖治疗前、胚胎移植、孕早期、孕中期、孕晚期及分娩时以及婴儿出生后42 d、6个月、1岁、3岁时采集数据信息和生物样本。其主要目标为评估使用辅助生殖技术后诞生子代的发育和健康状况，发现与不良出生结局和儿童期疾病相关的危险因素，为提升出生人口质量的策略制定提供科学依据。本文将对国家出生队列的建设概况和研究进展做简要介绍。 |
| English Abstract: |
| Birth cohort study has played an important role in exploring the effect of exposures in early life on long-term health of offspring. With the rapid increase of problems of reproductive health among couples at childbearing age, the assisted reproductive technology (ART) has been widely introduced into clinical practice. However, the influences of ART on long-term outcomes of mothers and infants have not been fully studied. In 2016, the China National Birth Cohort (CNBC), a multicenter prospective cohort study recruiting families with ART-conceived pregnancies and spontaneous-conceived pregnancies simultaneously was launched officially. By June 30, 2021, a total of 72 000 families covering 39 000 ART- pregnancies and 33 000 spontaneous- pregnancies have been recruited in the study, their information and biological samples were collected at multiple time points, i.e., before assisted reproductive treatment, in embryo transfer period, in first, second and third trimesters, at delivery, and at 42 days after birth, 6 months, 1 year old and 3 years old. The main objectives of this study are to assess the development and health of offspring born after ART treatment, identify risk factors associated with adverse birth outcomes and childhood diseases and provide scientific basis for the strategies to improve the quality of new birth population. This paper will give a brief introduction to the establishment and research progress of CNBC. |
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