| 宋扬,王盛书,王建伟,刘少华,陈仕敏,李雪航,赵亚力,李靖,朱乔,甯超学,王建华,刘淼,何耀.海南百岁老人营养状况对全因死亡影响的前瞻性队列研究[J].Chinese journal of Epidemiology,2023,44(1):122-127 |
| 海南百岁老人营养状况对全因死亡影响的前瞻性队列研究 |
| Effect of nutritional status on all-cause death in Hainan centenarians: a prospective cohort study |
| Received:April 13, 2022 |
| DOI：10.3760/cma.j.cn112338-20220413-00291 |
| KeyWord: 百岁老人 营养状况 全因死亡 死亡率 |
| English Key Word: Centenarian Nutrition status All-cause death Mortality rate |
| FundProject:国家自然科学基金（82173589，82173590，81941021）；首都卫生发展科研专项（2022-2G-5031）；国家重点研发计划（2018YFC2000400） |
| Author Name | Affiliation | E-mail | | Song Yang | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Health Corps, Special Combat Detachment of Xinjiang Armed Police Crops, Aksu 843000, China | | | Wang Shengshu | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Department of Healthcare, Agency for Offices Administration, Central Military Commission, People's Republic of China, Beijing 100082, China | | | Wang Jianwei | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Liu Shaohua | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Chen Shimin | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Li Xuehang | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Chinese People's Liberation Army Medical School, Beijing 100853, China | | | Zhao Yali | Central Laboratory, Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Li Jing | Health Service Department, Fifth Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Zhu Qiao | Central Laboratory, Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Ning Chaoxue | Central Laboratory, Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Wang Jianhua | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Liu Miao | Department of Statistics and Epidemiology, Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China | liumiaolmbxb@163.com | | He Yao | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
State Key Laboratory of Kidney Diseases, Beijing 100853, China | yhe301@sina.com |
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| Abstract: |
| 目的 探讨海南百岁老人营养状况与全因死亡风险之间的关系。方法 利用中国海南百岁老人队列研究2014-2021年调查数据，本研究共纳入1 002名基线资料完整的海南百岁老人，随访其生存与死亡结局。根据简易营养评估量表将百岁老人的营养状况分为营养良好（12~14分）、营养不良风险（8~11分）和营养不良（0~7分）3组。利用Kaplan-Meier曲线评估百岁老人的生存状况；利用Cox比例风险回归模型评估营养状况与全因死亡之间的关联。结果 2021年5月31日随访结束后，共发现522名百岁老人死亡，7年全因死亡率为52.10%（522/1 002）。与营养良好组相比，营养不良导致的平均减寿为0.62年。生存分析显示，营养不良组全因死亡率高于其他组（χ2=16.45，P<0.001）。多因素Cox比例风险回归分析结果显示，与营养良好的百岁老人相比，营养不良组全因死亡风险更高（HR=1.65，95%CI：1.18~2.31）。亚组分析发现女性百岁老人该关联更为显著。结论 营养不良与海南百岁老人高全因死亡风险相关，提示应及时评估和关注百岁老人特别是女性老人营养状况对其健康长寿及死亡的影响。 |
| English Abstract: |
| Objective To explore the association between nutritional status and all-cause death in the centenarians in Hainan Province. Methods Based on the survey data of China Hainan Centenarian Cohort Study from 2014 to 2021, a total of 1 002 Hainan centenarians with complete baseline data were included in this study, and their survival status and death outcome were surveyed. According to the Mini Nutritional Assessment Short-Form (MNA-SF), the centenarians were divided into three groups: well-nourished (12-14), at risk of malnutrition (8-11), and malnutrition (0-7). The survival status of the centenarians was evaluated by Kaplan-Meier curve. Cox proportional hazards regression model was used to assess the association between nutritional status and all-cause death. Results After the follow-up on May 31, 2021, we had found that 522 centenarians died, with an all-cause mortality rate of 52.10% (522/1 002). Compared with the well-nourished group, the average life lost caused by malnutrition was 0.62 years. Kaplan-Meier survival analysis showed that all-cause mortality rate was higher in the malnourished centenarians than in other groups (χ2=16.45, P<0.001). Multivariate Cox proportional hazards regression model showed that the risk of all-cause mortality rate in malnourished centenarians was higher than that in well-nourished centenarians (HR=1.65, 95%CI: 1.18-2.31). Subgroup analysis found that the association in female centenarians was more significant. Conclusions Malnutrition was associated with a high risk of all-cause death in Hainan centenarians. It is suggested that we should timely evaluate and pay attention to the impact of nutritional status of centenarians on their health and longevity, and death, especially in the female elderly. |
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