| 贾鑫华,匡雪凤,陈亚涵,李煜霏,毕兆峰,吴婷,乔友林.人乳头瘤病毒疫苗长期保护效力研究进展[J].Chinese journal of Epidemiology,2023,44(5):851-854 |
| 人乳头瘤病毒疫苗长期保护效力研究进展 |
| Progress in research of long-term protective efficacy of human papillomavirus vaccine |
| Received:October 25, 2022 |
| DOI：10.3760/cma.j.cn112338-20221025-00905 |
| KeyWord: 宫颈癌 人乳头瘤病毒疫苗 效力 长期随访 |
| English Key Word: Cervical cancer Human papillomavirus vaccine Efficacy Long-term follow-up |
| FundProject:中国医学科学院医学与健康科技创新工程(2021-I2M-1-004) |
| Author Name | Affiliation | E-mail | | Jia Xinhua | The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China
Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences&
Peking Union Medical College, Beijing 100021, China | | | Kuang Xuefeng | The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China
Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences&
Peking Union Medical College, Beijing 100021, China | | | Chen Yahan | Yanjing Medical College, Capital Medical University, Beijing 101300, China | | | Li Yufei | The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China
Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences&
Peking Union Medical College, Beijing 100021, China | | | Bi Zhaofeng | The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China | | | Wu Ting | The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China | | | Qiao Youlin | The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China
Center for Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences&
Peking Union Medical College, Beijing 100730, China | qiaoy@cicams.ac.cn |
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| Abstract: |
| HPV疫苗对宫颈癌的预防作用已经在众多临床试验和真实世界中得到验证。其中试验人群的随访年限一般为5~6年。临床试验结束后，为了验证疫苗的长期有效性，部分地区开展了系列长期随访研究，本文检索了目前国内外对HPV疫苗长期保护效力相关研究。目前公开的数据显示对疫苗保护型别相关的宫颈上皮内瘤病变2级及以上保护效力均高于90%。 |
| English Abstract: |
| The efficacy of HPV vaccine in preventing cervical cancer has been demonstrated in numerous clinical trials and clinical uses. The follow-up after clinical trials usually last for 5-6 years to evaluate the long-term efficacy, and a series of long-term follow-up studies have been conducted in some regions. The literature retrieval of HPV vaccine long term efficiency research both at home and abroad indicated that the protective efficacy of the vaccine against vaccine-type-related cervical intraepithelial neoplasia grade 2 and above is higher than 90%. |
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