中国儿童型复发性呼吸道乳头状瘤病患者HPV感染率及型别分布特征

敦畅畅; 李雨桐; 赵雪莲; 赵方辉

Abstract

敦畅畅,李雨桐,赵雪莲,赵方辉.中国儿童型复发性呼吸道乳头状瘤病患者HPV感染率及型别分布特征[J].Chinese journal of Epidemiology,2023,44(6):990-998

中国儿童型复发性呼吸道乳头状瘤病患者HPV感染率及型别分布特征

Human papillomavirus prevalence and type distribution in Chinese juvenile-onset recurrent respiratory papillomatosis patients

Received:November 03, 2022

DOI：10.3760/cma.j.cn112338-20221103-00937

KeyWord: 复发性呼吸道乳头状瘤病人乳头瘤病毒感染率 Meta分析

English Key Word: Recurrent respiratory papillomatosis Human papillomavirus Infection rate Meta-analysis

FundProject:中国医学科学院医学与健康科技创新工程（2021-I2M-1-004）

Author Name	Affiliation	E-mail
Dun Changchang	Department of Population Medicine, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Li Yutong	Department of Population Medicine, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Zhao Xuelian	Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Zhao Fanghui	Department of Population Medicine, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China	zhaofangh@cicams.ac.cn

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Abstract:

目的系统评估与定量分析中国儿童型复发性呼吸道乳头状瘤病（JoRRP）患者HPV感染率及型别分布特征。方法从中国知网、万方数据知识服务平台、中国生物医学文献数据库、PubMed、Embase和Cochrane Library中检索关于JoRRP患者HPV感染特征的研究，发表时间截至2022年10月1日。由2名研究人员按照预先制定的标准独立进行文献筛选、数据提取和文献质量评价。研究指标包括患者HPV总体感染率和型别特异性感染率。对率进行双反正弦变换后采用随机效应模型计算合并效应值。采用R 4.1.3软件进行统计学分析。结果共纳入19项符合标准的研究，其中16项报告了HPV感染率，样本量为1 528名，11项报告了HPV6和HPV11感染率，样本量为611名。所有研究被评为中等质量。Meta分析结果显示，中国JoRRP患者HPV感染率为92.0%（95%CI：86.0%~96.6%，I²=87%），HPV6感染率为42.4%（95%CI：34.9%~50.1%，I²=61%），HPV11感染率为72.3%（95%CI：59.0%~83.9%，I²=87%），上述合并效应值不随发表年限、样本量、检测标本来源等因素发生显著改变（P>0.05），研究结果未显示发表偏倚。JoRRP患者HPV16、18、31、33、52和58等型别感染罕见。结论中国JoRRP患者的HPV感染率较高，以HPV6和HPV11感染为主。

English Abstract:

Objective To evaluate HPV prevalence and type distribution in Chinese juvenile-onset recurrent respiratory papillomatosis (JoRRP) patients. Methods We searched China National Knowledge Infrastructure, Wanfang data, China Biology Medicine disc, PubMed, Embase, and the Cochrane Library for studies assessing HPV infection of Chinese JoRRP patients up to 1 October, 2022. Two authors independently performed literature selection, data extraction, and quality assessment. HPV prevalence and HPV type-specific prevalence were pooled using a random effects model after Freeman-Tukey double arcsine transformation. All analyses were performed with R 4.1.3 software. Results Nineteen publications investigating HPV infection of JoRRP patients were included in the final analyses. Of these, 16 studies reported HPV prevalence with a sample size of 1 528 patients, and 11 studies reported HPV6 prevalence and HPV11 prevalence with a sample size of 611 patients. All studies were graded as medium quality. In Chinese JoRRP patients, the synthesized HPV prevalence was 92.0% (95%CI:86.0%-96.6%, I²=87%), HPV6 prevalence was 42.4% (95%CI:34.9%-50.1%, I²=61%), and HPV11 prevalence was 72.3% (95%CI:59.0%-83.9%, I²=87%). All the pooled prevalence persisted in subgroup analyses stratified by publication year, sample size, and specimen type (P>0.05). There was no evidence of publication bias. In Chinese JoRRP patients, HPV16, 18, 31, 33, 52, and 58 prevalence was very low. Conclusions Our findings suggested high HPV prevalence in Chinese JoRRP patients, and the most common HPV types were HPV6 and HPV11.

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