| 朱乔,陈仕敏,李皓炜,李蓉蓉,杨姗姗,王盛书,赵亚力,甯超学,刘淼,何耀.海南女性百岁老人性激素水平与全因死亡的关联分析[J].Chinese journal of Epidemiology,2023,44(8):1245-1250 |
| 海南女性百岁老人性激素水平与全因死亡的关联分析 |
| Association analysis between sex hormone levels and all-cause mortality in Hainan female centenarians |
| Received:November 30, 2022 |
| DOI：10.3760/cma.j.cn112338-20221130-01015 |
| KeyWord: 性激素 全因死亡 女性百岁老人 |
| English Key Word: Sex hormones All-cause mortality Female centenarian |
| FundProject:国家自然科学基金（81941021，82173589，82173590）；国家重点研发计划（2018YFC2000400）；军队保健专项（22BJZ25）；国家科技资源共享服务平台计划（YCZYPT［2018］07）；海南省自然科学基金面上项目（820MS126）；海南省院士创新平台科研专项（YSPTZX202216） |
| Author Name | Affiliation | E-mail | | Zhu Qiao | Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Chen Shimin | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Li Haowei | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Li Rongrong | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Yang Shanshan | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Wang Shengshu | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Zhao Yali | Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Ning Chaoxue | Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Liu Miao | Department of Statistics and Epidemiology, Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China | liumiaolmbxb@163.com | | He Yao | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | yhe301@sina.com |
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| Abstract: |
| 目的 探讨海南女性百岁老人性激素分布特征及与全因死亡的关系。方法 研究对象来自中国海南百岁老人队列研究,共717名符合条件的女性百岁老人纳入分析。采用Kaplan-Meier法绘制生存曲线,Cox比例风险回归模型分析性激素与生存时间的关系。结果 海南女性百岁老人雌二醇和孕酮的M(Q1,Q3)为32.60(18.40,58.70)pmol/L和0.62(0.32,1.01)nmol/L。存活组与死亡组雌二醇(pmol/L)和孕酮(nmol/L)分别为26.65 vs. 37.80、0.54 vs. 0.69,差异有统计学意义(P<0.05)。Cox比例风险回归模型分析结果显示,雌二醇和孕酮与死亡关联差异有统计学意义(P<0.05),雌二醇Q4组的风险比(HR)值为1.58(95%CI:1.17~2.15),孕酮Q3和Q4组的HR值分别为1.53(95%CI:1.10~2.12)和1.63(95%CI:1.15~2.32)。亚组和交互分析结果显示,雌二醇与高血压、糖尿病和低HDL-C血症差异有统计学意义(P<0.05),且孕酮与糖尿病存在交互作用(P=0.016),睾酮与低HDL-C血症存在交互作用(P=0.034)。结论 海南女性百岁老人雌激素水平与较高的死亡风险有关,且与心血管代谢疾病(如糖尿病、高血压、脂代谢异常)的发病风险增加有关。 |
| English Abstract: |
| Objective To investigate the distribution characteristics of sex hormones and their relationship with all-cause mortality in Hainan female centenarians. Methods All the subjects were from China Hainan Centenarian Cohort Study. A total of 717 female centenarians were included in the final analysis. Kaplan-Meier method was used to draw the survival curve, and Cox proportional hazard regression was used to analyze the relationship between sex hormones and survival time. Results The M(Q1, Q3) of estradiol and progesterone among female centenarians was 32.60 (18.40, 58.70) pmol/L and 0.62 (0.32, 1.01) nmol/L. The estradiol (pmol/L) and progesterone (nmol/L) in the survival and death groups were 26.65 vs.37.80, 0.54 vs.0.69, respectively, with statistical differences (P<0.05). Cox multivariate analysis showed that estradiol and progesterone were significantly associated with death (P<0.05), the hazard ratio (HR) of estradiol Q4 was 1.58 (95%CI:1.17-2.15), and the HR of progesterone Q3 was 1.53 (95%CI:1.10-2.12), HR for Q4was 1.63 (95%CI:1.15-2.32). Subgroup and cross-analysis showed that estradiol was statistically significant with hypertension, diabetes, and low high-density lipoprotein cholesterol (P<0.05), and progesterone interacted with diabetes (P=0.016), while testosterone interacted with low high-density lipoprotein cholesterol (P=0.034). Conclusion It is suggested that the estrogen levels of female centenarians in Hainan were associated with a higher mortality risk and an increased risk of cardiovascular metabolic disease (such as diabetes, hypertension, and abnormal lipid metabolism). |
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