| 杨逢遇,陶芳标.母体免疫激活与儿童神经发育障碍[J].Chinese journal of Epidemiology,2023,44(9):1491-1496 |
| 母体免疫激活与儿童神经发育障碍 |
| Association between maternal immune activation and neurodevelopmental disorders in children |
| Received:February 22, 2023 |
| DOI：10.3760/cma.j.cn112338-20230222-00095 |
| KeyWord: 母体免疫激活 神经发育障碍 流行病学 |
| English Key Word: Maternal immune activation Neurodevelopmental disorder Epidemiology |
| FundProject:国家自然科学基金（U22A20361） |
| Author Name | Affiliation | E-mail | | Yang Fengyu | Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University/Key Laboratory of Population Health Across Life Cycle, Ministry of Education/Anhui Province Key Laboratory of Population Health and Aristogenics/National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei 230032, China | | | Tao Fangbiao | Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University/Key Laboratory of Population Health Across Life Cycle, Ministry of Education/Anhui Province Key Laboratory of Population Health and Aristogenics/National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei 230032, China | fbtao@ahmu.edu.cn |
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| Abstract: |
| 孕期作为一个特殊时期，母体易遭受不良暴露进而影响子代。孕期母亲免疫失衡出现母体免疫激活（MIA），会影响后代神经发育，流行病学研究证据支持MIA与后代神经发育障碍（NDDs）之间的关联，多种因素如遗传背景、母体营养状况、母体肠道微生物等可影响两者间的关联强度。研究表明MIA会通过多种途径影响后代大脑突触形成和修剪，胎盘也在两者关联间起作用。本文综述了近年来MIA与儿童NDDs关联的研究现状，为预防NDDs发生提供思路和方向。 |
| English Abstract: |
| During pregnancy, as a special period, mother is vulnerable to adverse exposure, affecting the health of offspring. Maternal immune activation (MIA) due to maternal immune imbalance during pregnancy can affect the neurodevelopment of offspring. Evidence from epidemiological studies and animal studies supports an association between MIA and neurodevelopmental disorders (NDDs) in offspring. A variety of factors, such as genetic background, maternal nutritional status and maternal gut microbes, can influence the strength of the association. Studies have shown that MIA affects synapsis formation and pruning in offspring through a variety of pathways, and the placenta also plays a role in such association. This article summarizes the recent research of the association between MIA and neurodevelopmental disorders in children, and provides suggestion for the prevention of the incidence of NDDs. |
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