抗病毒治疗男男性行为人群HIV感染者对“检测不到等于无传染性”理念的认知调查

张克春; 孟晓军; 胡甜; 罗丹; 曹赫; 林启辉; 邹华春

Abstract

张克春,孟晓军,胡甜,罗丹,曹赫,林启辉,邹华春.抗病毒治疗男男性行为人群HIV感染者对“检测不到等于无传染性”理念的认知调查[J].Chinese journal of Epidemiology,2023,44(10):1610-1615

抗病毒治疗男男性行为人群HIV感染者对“检测不到等于无传染性”理念的认知调查

Survey on the cognition of the “undetectable equals untransmittable” concept among HIV-infected men who have sex with men receiving antiviral treatment

Received:April 24, 2023

DOI：10.3760/cma.j.cn112338-20230424-00264

KeyWord: 艾滋病病毒男男性行为人群病毒载量认知

English Key Word: HIV Men who have sex with men Viral load Cognition

FundProject:深圳市龙华区引进高层次医学团队项目（HLPM201907020105）；国家自然科学基金优秀青年项目（82022064）；无锡市科技局项目（Y20222006）

Author Name	Affiliation	E-mail
Zhang Kechun	Longhua District Centre for Disease Control and Prevention, Shenzhen 518109, China
Meng Xiaojun	Wuxi Prefectural Centre for Disease Control and Prevention, Wuxi 214023, China
Hu Tian	Longhua District Centre for Disease Control and Prevention, Shenzhen 518109, China
Luo Dan	School of Public Health(Shenzhen), Sun Yat-sen University, Shenzhen 518107, China
Cao He	Longhua District Centre for Disease Control and Prevention, Shenzhen 518109, China
Lin Qihui	Longhua District Centre for Disease Control and Prevention, Shenzhen 518109, China
Zou Huachun	School of Public Health(Shenzhen), Sun Yat-sen University, Shenzhen 518107, China	zouhuachun@mail.sysu.edu.cn

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Abstract:

目的了解深圳市抗病毒治疗MSM HIV感染者（MSM感染者）对“检测不到等于无传染性”（“U=U”）理念的认知状况，并分析影响其认知的因素，为制定针对该理念的宣传和倡导策略提供依据。方法结合HIV感染者日常随访，在深圳市通过方便抽样招募抗病毒治疗MSM感染者为研究对象，开展横断面调查，估算样本量为475例。利用调查问卷收集研究对象的社会人口学、性行为、抗病毒治疗、病毒载量检测信息，以及对“U=U”理念的认知情况等内容，并采用logistic回归模型分析影响研究对象接受“U=U”理念的相关因素。结果共490例抗病毒治疗MSM感染者，其中知晓“U=U”理念的占60.2%（295/490），接受“U=U”理念的占50.6%（248/490）。多因素logistic回归分析结果显示，大专及以上文化程度（aOR=1.76，95%CI：1.12~2.75）的研究对象更可能接受“U=U”理念；无本地户籍（aOR=0.51，95%CI：0.29~0.92）、最近1次病毒载量检测结果>0拷贝数/ml（aOR=0.61，95%CI：0.38~0.98）和不知晓“U=U”理念（aOR=0.13，95%CI：0.09~0.21）的研究对象更可能不接受“U=U”理念。结论深圳市抗病毒治疗MSM感染者对“U=U”理念的认知仍处于较低水平，应结合其日常随访，通过医务人员加大对该理念的宣传和倡导力度，提高MSM感染者抗病毒治疗的依从性和治疗的效果。同时，要根据MSM感染者的人群特点，制定相关工作指南，提高“U=U”理念宣传和倡导工作的规范性。

English Abstract:

Objective To explore the cognition of the "undetectable equals untransmittable" ("U=U") concept and associated factors among HIV-infected men who have sex with men (MSM) receiving antiviral treatment (ART) in Shenzhen, and provide evidence for designing promotion and advocacy strategies for the "U=U" concept. Methods We recruited HIV-infected MSM receiving ART using convenient sampling method combined with routine follow-up in Shenzhen through conducting observational survey. The sample size was estimated to be 475. A questionnaire was administered to collect socio-demographic characteristics, sexual behaviors, ART, viral load testing and the cognition towards "U=U" in HIV-infected MSM. Logistic regression was used to access factors associated with acceptance of "U=U". Results A total of 490 HIV-infected MSM receiving ART were recruited. Of whom, 60.2% (295/490) were aware of "U=U" and 50.6% (248/490) accepted "U=U". Multiple logistic regression showed that participants who had an educational level of college or above (aOR=1.76,95%CI: 1.12-2.75) were more likely to accept "U=U". Those who had no local residency (aOR=0.51,95%CI: 0.29-0.92), had viral load >0 copies/ml in the last testing (aOR=0.61,95%CI: 0.38-0.98) and were unaware of "U=U" (aOR=0.13, 95%CI: 0.09-0.21), were less likely to accept "U=U". Conclusions HIV-infected MSM receiving ART had a low cognition level of "U=U" in Shenzhen. Promotion and advocacy on this concept through healthcare workers should be enhanced in combination with routine follow-up in order to improve their ART adherence and outcome of treatment. Furthermore, developing related guidelines on "U=U" according to the characteristics of HIV-infected individuals is warranted to improve the normalization of promotion and advocacy on "U=U".

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