| 杨喆,刘博蕊,万宁钰,王小川,郑璐,胡嘉晋,闻德亮.母乳喂养对生命早期危险因素与儿童肥胖关联的修饰作用研究进展[J].Chinese journal of Epidemiology,2023,44(11):1843-1848 |
| 母乳喂养对生命早期危险因素与儿童肥胖关联的修饰作用研究进展 |
| Progress in research of modification effect of breastfeeding on association between early life risk factors and childhood obesity |
| Received:March 13, 2023 |
| DOI：10.3760/cma.j.cn112338-20230313-00143 |
| KeyWord: 儿童肥胖 母乳喂养 遗传 环境 修饰作用 |
| English Key Word: Childhood obesity Breastfeeding Heredity Environment Modification effect |
| FundProject:国家自然科学基金（82103860） |
| Author Name | Affiliation | E-mail | | Yang Zhe | Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases of Liaoning Province/Health Sciences Institute, China Medical University, Shenyang 110122, China | | | Liu Borui | Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases of Liaoning Province/Health Sciences Institute, China Medical University, Shenyang 110122, China | | | Wan Ningyu | Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases of Liaoning Province/Health Sciences Institute, China Medical University, Shenyang 110122, China | | | Wang Xiaochuan | Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases of Liaoning Province/Health Sciences Institute, China Medical University, Shenyang 110122, China | | | Zheng Lu | Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases of Liaoning Province/Health Sciences Institute, China Medical University, Shenyang 110122, China | | | Hu Jiajin | Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases of Liaoning Province/Health Sciences Institute, China Medical University, Shenyang 110122, China | | | Wen Deliang | Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases of Liaoning Province/Health Sciences Institute, China Medical University, Shenyang 110122, China | dlwen@cmu.edu.cn |
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| Abstract: |
| 儿童肥胖已成为全球共同关注的公共健康问题，其发生发展与生命早期危险因素暴露密切相关。近年来，越来越多流行病学研究证据显示，母乳喂养对儿童肥胖的生命早期危险因素如肥胖高遗传风险、母亲患妊娠糖尿病、出生巨大儿等因素带来的健康危险效应具有修饰作用。本文通过对该领域现有的研究结果进行综述，总结母乳喂养对儿童肥胖遗传及生命早期环境危险因素的修饰作用，为明确母乳喂养对特定高危儿童的肥胖防控效益和实施针对性的防控策略提供参考。 |
| English Abstract: |
| Childhood obesity has become a global public health problem, and its incidence and development are closely related to the exposure to risk factors in early life. In recent years, more and more epidemiological research evidences have shown that breastfeeding has the modification effect on early life risk factors of childhood obesity, such as high genetic risk of obesity, maternal gestational diabetes mellitus, macrosomia and other factors. This paper reviews the research results in this field, and summarizes the modification effect of breastfeeding on childhood obesity heredity and early life environmental risk factors associated with childhood obesity, to provide a reference for the evaluation of positive effect of breastfeeding on prevention and control of obesity in specific risk groups for taking targeted measure to reduce the risk for childhood obesity. |
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