海南高龄老人头发微量元素水平与全因死亡的关联分析

朱乔; 李晶; 付士辉; 甯超学; 陈玉剑; 杨婷; 周汉王; 刘淼; 何耀; 赵亚力

Abstract

朱乔,李晶,付士辉,甯超学,陈玉剑,杨婷,周汉王,刘淼,何耀,赵亚力.海南高龄老人头发微量元素水平与全因死亡的关联分析[J].Chinese journal of Epidemiology,2023,44(12):1936-1942

海南高龄老人头发微量元素水平与全因死亡的关联分析

Association between hair trace element and all-cause death in elderly people in Hainan

Received:April 20, 2023

DOI：10.3760/cma.j.cn112338-20230420-00257

KeyWord: 微量元素全因死亡高龄老人

English Key Word: Trace element All-cause death Elderly people

FundProject:海南省自然科学基金（820MS126，823MS161，821QN389）；海南省卫生健康科技创新联合项目（SQ2023WSJK0633）

Author Name	Affiliation	E-mail
Zhu Qiao	Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China
Li Jing	Birth Defects Prevention and Control Technology Research Center, Medical Innovation Research Department, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Fu Shihui	Department of Cardiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya 572013, China
Ning Chaoxue	Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China
Chen Yujian	Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China
Yang Ting	Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China
Zhou Hanwang	Clinical Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China
Liu Miao	Department of Statistics and Epidemiology, Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China
He Yao	Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China	yhe301@sina.com
Zhao Yali	Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China	zhaoyl301@163.com

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Abstract:

目的探讨海南高龄老人头发微量元素水平与全因死亡的关系。方法研究对象来自于中国海南百岁老人队列研究的部分高龄老人，共163名。采用Cox比例风险回归模型分析头发微量元素与全因死亡的关系。结果海南高龄老人元素硒（Se）、锰（Mn）、锶（Sr）与死亡关联的风险比（HR）差异有统计学意义，HR值分别为0.72（95%CI：0.54~0.98，P=0.035）、1.50（95%CI：1.07~2.11，P=0.020）、0.54（95%CI：0.37~0.79，P=0.001）。按贫血进行亚组和交互分析并进行多因素调整后，元素铜与贫血人群死亡关联的HR值为1.81（95%CI：1.13~2.88，P=0.013）。此外，Mn与贫血存在交互作用，HR值为0.46（95%CI：0.22~0.94，P=0.033）。结论海南高龄老人头发Se、Mn、Sr含量与全因死亡风险增加密切相关，头发Se、Mn、Sr可作为长寿老人死亡风险预测的参考指标，提示注重高龄老人的日常饮食，应丰富多样，以维持体内微量元素含量的正常与均衡。

English Abstract:

Objective To explore the association between hair trace element and all-cause death in the elderly in Hainan Province. Methods The subjects of the study were elderly people from China Hainan Centenarian Cohort Study, a total of 163 elderly were included. The association between hair trace element level and all-cause death was analyzed by using Cox proportional risk regression model. Results After fully adjusting the covariates, the multiple Cox proportional hazards regression analyses showed that selenium (Se), manganese (Mn), strontium (Sr) concentrations in hair were significantly associated with all-cause mortality, the hazard ratio (HR) were 0.72 (95%CI: 0.54-0.98, P=0.035), 1.50 (95%CI: 1.07-2.11, P=0.020) and 0.54 (95%CI: 0.37-0.79, P=0.001), respectively. Subgroup and cross analysis showed that hair copper (Cu) were significant association with death in the people with anemia, the HR were 1.81 (95%CI: 1.13-2.88, P=0.013). And, hair Mn interacted with anemia, the HR was 0.46 (95%CI: 0.22-0.94, P=0.033).Conclusions Se, Mn and Sr concentrations in hair were associated with the elevated risk for all-cause death in the elderly in Hainan. Se, Mn and Sr concentrations in hair can be used as a reference index for the prediction of the death risk of long-lived elderly in community, suggesting that the daily diet of elderly people are rich and diverse, in order to maintain normal and balanced trace element content in the body.

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