| 李皓炜,齐士格,王盛书,杨姗姗,陈仕敏,李蓉蓉,李雪航,刘少华,杨钧涵,李怀昊,鲍颖慧,石岳庭,王志会,何耀,刘淼.中国社区老年人脑认知相关生活方式对早期认知功能下降的影响[J].Chinese journal of Epidemiology,2024,45(1):63-70 |
| 中国社区老年人脑认知相关生活方式对早期认知功能下降的影响 |
| Effects of cognition-related lifestyles on early cognitive decline in community older adults in China |
| Received:May 18, 2023 |
| DOI：10.3760/cma.j.cn112338-20230518-00310 |
| KeyWord: 认知功能 生活方式 老年人 队列研究 |
| English Key Word: Cognition Lifestyle Elderly Cohort study |
| FundProject:国家重点研发计划（2020YFC2008700，2022YFC2503605）；财政部重大公共卫生专项（131091106000150003）；国家自然科学基金（82173589，82173590）；首都卫生发展科研专项（2022-2G-5031） |
| Author Name | Affiliation | E-mail | | Li Haowei | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Qi Shige | National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | | Wang Shengshu | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Yang Shanshan | Department of Disease Prevention and Control, the First Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Chen Shimin | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Li Rongrong | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Li Xuehang | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Liu Shaohua | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Yang Junhan | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Department of anti Nuclear, Biological and Chemical medicine, Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Li Huaihao | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Bao Yinghui | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Shi Yueting | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Department of anti Nuclear, Biological and Chemical medicine, Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Wang Zhihui | National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | | He Yao | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
State Key Laboratory of Kidney Diseases, Beijing 100853, China | yhe301@sina.com | | Liu Miao | Department of anti Nuclear, Biological and Chemical medicine, Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China | liumiaolmbxb@163.com |
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| Abstract: |
| 目的 了解中国社区老年人脑认知相关生活方式的分布特征，并探讨其综合评分对早期认知功能下降的影响。方法 研究对象来自老年期重点疾病预防和干预项目。纳入2015年基线调查及2017年随访调查均完成认知功能状况评定，且基线未患痴呆的2 537名≥60岁的社区老年人。通过问卷调查收集其脑认知相关生活方式信息（体育锻炼、社会交往、脑力休闲活动、睡眠质量、吸烟状况与饮酒状况）并计算综合评分。通过多因素logistic回归模型分析脑认知相关生活方式综合评分与早期认知功能下降的关联。结果 2 537名社区老年人群中，评分5~6分者占28.7%，6项脑认知相关生活方式因子均健康者仅占4.8%。男性与女性的健康生活方式因子分布存在差异。多因素logistic回归模型结果显示，与评分0~3分组相比，评分4分和5~6分组早期认知功能下降的风险降低（OR=0.683，95%CI：0.457~1.019；OR=0.623，95%CI：0.398~0.976；趋势P=0.030）。在女性中，与评分0~3分组相比，评分4分和5~6分组的早期认知功能下降的风险降低（OR=0.491，95%CI：0.297~0.812；OR=0.556，95%CI：0.332~0.929；趋势P=0.024）。结论 脑认知相关综合健康生活方式与早期认知功能下降风险降低密切相关，在女性群体中尤为显著。 |
| English Abstract: |
| Objective To investigate the distribution characteristics of cognition-related lifestyles of elderly in communities and explore the integrated effects on early cognitive decline. Methods The participants were from the Project of Prevention and Intervention of Neurodegenerative Disease for Elderly in China. A total of 2 537 older adults aged ≥60 years without dementia in the 2015 baseline survey and the 2017 follow-up survey were included. The information about their cognition-related lifestyles, including physical exercise, social interaction, leisure activity, sleep quality, smoking status, and alcohol consumption, were collected through questionnaire survey and the integrated scores were calculated. Multivariate logistic regression analysis was used to assess the association between integrated cognition-related lifestyle score and early cognitive decline. Results In the 2 537 older adults surveyed, 28.7% had score of 5-6, while only 4.8% had high scores for all 6 healthy lifestyles. Significant differences in healthy lifestyle factor distributions were observed between men and women. Multivariate logistic regression model showed that the risks for early cognitive decline in the older adults who had lifestyle score of 4 and 5-6 were lower than that in those with lifestyle score of 0-3 (OR=0.683, 95%CI: 0.457-1.019; OR=0.623, 95%CI: 0.398-0.976; trend P=0.030). In the women, the risks for early cognitive decline was lower in groups with score of 4 and 5-6 than in group with score of 0-3 (OR=0.491, 95%CI: 0.297-0.812; OR=0.556, 95%CI: 0.332-0.929; trend P=0.024). Conclusion Cognition-related healthy lifestyles are associated with significantly lower risk for early cognitive decline in the elderly, especially in women. |
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