| 董俣君,郭雁飞,阮晔,孙双圆,蒋安丽,汪嘉琦,施燕,吴凡.上海市50岁及以上人群维生素D水平与握力的关联研究[J].Chinese journal of Epidemiology,2024,45(3):393-400 |
| 上海市50岁及以上人群维生素D水平与握力的关联研究 |
| Association between vitamin D level and grip strength in adults aged 50 and older in Shanghai |
| Received:June 30, 2023 |
| DOI：10.3760/cma.j.cn112338-20230630-00409 |
| KeyWord: 维生素D 握力 中老年人 |
| English Key Word: Vitamin D Grip strength Middle-aged and elderly people |
| FundProject:美国国立老龄研究所（R01-AG034479）；上海市卫生健康委员会项目（20204Y0196，2020YJZX0113，GWVI-8，GWVI-11.1-22，GWVI-11.1-25，201840118） |
| Author Name | Affiliation | E-mail | | Dong Yujun | Division of Chronic and Non-communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Guo Yanfei | Shanghai Institute of Preventive Medicine, Shanghai 200336, China | | | Ruan Ye | Division of Chronic and Non-communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Sun Shuangyuan | Division of Chronic and Non-communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Jiang Anli | Division of Chronic and Non-communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Wang Jiaqi | Division of Chronic and Non-communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Shi Yan | Division of Chronic and Non-communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | shiyan@scdc.sh.cn | | Wu Fan | Office for Shanghai Medical College, Fudan University, Shanghai 200032, China | wufan@shmu.edu.cn |
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| Abstract: |
| 目的 探讨上海市≥50岁人群维生素D水平与握力的关系。方法 数据来源于WHO全球老龄化与成人健康研究我国上海市2018-2019年数据，采用logistic回归模型分析维生素D水平与握力的关系，进一步按照性别、年龄及乳制品摄入情况进行分层；采用限制性立方样条曲线绘制维生素D水平与低握力的剂量-反应曲线。结果 共4 391人纳入研究，其中男性2 054人（46.8%）；年龄（67.02±8.81）岁；低握力1 421人（32.4%）；维生素D不足及缺乏分别为1 533人（34.9%）和401人（9.1%）。在调整相关混杂因素后，logistic回归分析结果显示，维生素D缺乏的人群发生低握力的风险更高（OR=1.41，95%CI：1.09~1.83）；在男性中，调整相关混杂因素后，维生素D缺乏与低握力发生风险呈显著正相关（OR=1.67，95%CI：1.12~2.50），而女性中两者之间无关联（OR=1.30，95%CI：0.97~1.74）；在60~69岁及≥80岁年龄组中，调整相关混杂因素后，维生素D缺乏与低握力发生风险呈显著正相关（OR=1.57，95%CI：1.05~2.35；OR=2.40，95%CI：1.08~5.31），在乳制品摄入<250 ml/d的人群中，调整相关混杂因素后，二者之间呈显著正相关（OR=1.57，95%CI：1.17~2.09），而在乳制品摄入≥250 ml/d的人群中无明显关联。限制性立方条样图显示，低握力的发生风险可能随维生素D含量的上升而降低，但差异无统计学意义（P>0.05）。结论 维生素D水平与握力存在一定的关系，维生素D缺乏人群出现低握力的风险更高。 |
| English Abstract: |
| Objective To understand the association between vitamin D level and grip strength in people aged ≥50 years in Shanghai. Methods Data were obtained from the WHO's Study on Global Ageing and Adult Health in Shanghai during 2018-2019. Logistic regression model was used to analyze the association between vitamin D level and grip strength, and a stratified analysis was conducted for different gender, age and dairy product intake groups. Restricted cubic spline was used to evaluate the dose-response association between vitamin D level and low grip strength. Results A total of 4 391 participants were included in the study, including 2 054 men (46.8%), with an average age of (67.02±8.81) years. And 1 421 individuals (32.4%) had low grip strength; 1 533 individuals (34.9%) had vitamin D deficiency, and 401 individuals (9.1%) had vitamin D deficiency. After adjusted for confounding factors, the logistic regression results analysis showed that individuals with vitamin D deficiency had a higher risk for low grip strength (OR=1.41, 95%CI: 1.09-1.83). In men, after adjusting for confounding factors, vitamin D deficiency was positively associated with the risk for low grip strength (OR=1.67, 95%CI: 1.12-2.50), but there was no significant association between vitamin D level and grip strength in women (OR=1.30, 95%CI: 0.97-1.74). In age group 60-69 years and ≥80 years, there was significant association between vitamin D deficiency and low grip strength after adjusting for confounding factors (OR=1.57, 95%CI: 1.05-2.35; OR=2.40, 95%CI: 1.08-5.31). In people who had daily intake of dairy product <250 ml, there was positive association between vitamin D deficiency and low grip strength, but there was no significant association in people who had daily dairy product ≥250 ml after adjusting for confounding factors. The restrictive cubic spline demonstrated that risk of low grip strength might decreased with the increase of vitamin D levels, however, the difference was not significant (P>0.05). Conclusions This study demonstrated that there is association between vitamin D level and grip strength. People with vitamin D deficiency have higher risk for low grip strength. |
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