Abstract
陈子婷,高健,钟文芳,黄清湄,陈沛良,宋玮琦,王晓萌,钟逸诗,施小明,毛琛.中国8个长寿地区65岁及以上老年人血尿素氮与肌酐比值和衰弱的关联[J].Chinese journal of Epidemiology,2024,45(5):666-672
中国8个长寿地区65岁及以上老年人血尿素氮与肌酐比值和衰弱的关联
Effects of blood urea nitrogen to creatinine ratio on frailty in the elderly aged 65 years and older in 8 longevity areas in China
Received:October 20, 2023  
DOI:10.3760/cma.j.cn112338-20231020-00240
KeyWord: 老年人  血尿素氮与肌酐比值  衰弱  队列研究
English Key Word: Elderly  Blood urea nitrogen to creatinine ratio  Frailty  Cohort study
FundProject:广东省高水平大学建设计划(G623330580,G621331128);广东省高等学校珠江学者岗位计划(2019)
Author NameAffiliationE-mail
Chen Ziting Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China  
Gao Jian Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China  
Zhong Wenfang Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China  
Huang Qingmei Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China  
Chen Peiliang Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China  
Song Weiqi Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China  
Wang Xiaomeng Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China  
Zhong Yishi Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China  
Shi Xiaoming China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China shixm@chinacdc.cn 
Mao Chen Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China maochen9@smu.edu.cn 
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Abstract:
      目的 探讨中国8个长寿地区≥65岁老年人血尿素氮与肌酐比值和衰弱的关联。方法 研究对象来自老年健康生物标志物队列,利用血尿素氮与肌酐的基线信息和随访获得的衰弱事件,将血尿素氮与肌酐比值按五分位数分组,采用Cox比例风险回归模型分析血尿素氮与肌酐比值和衰弱发生风险的关联。结果 共纳入1 562名研究对象,年龄(81.0±17.0)岁,其中男性814名(52.1%)。(3.73±1.43)年随访期间共发生衰弱事件258名。Cox比例风险回归模型分析结果显示,在调整相关的混杂因素后,与血尿素氮与肌酐比值Q1组相比,Q3Q4Q5组的衰弱发生风险分别降低了36%[风险比(HR)=0.64,95%CI:0.43~0.94]、44%(HR=0.56,95%CI:0.38~0.84)和40%(HR=0.60,95%CI:0.41~0.88)。血尿素氮与肌酐比值每增加一个标准差,衰弱发生风险降低20%(HR=0.80,95%CI:0.70~0.91)。血尿素氮与肌酐比值和衰弱发生风险呈近线性剂量-反应关系。结论 衰弱发生风险随着血尿素氮与肌酐比值的增加而呈下降趋势,维持较高的血尿素氮与肌酐比值对于预防老年人衰弱具有重要意义。
English Abstract:
      Objective To explore the relationship between blood urea nitrogen to creatinine ratio and frailty in the elderly aged ≥65 years in 8 longevity areas in China. Methods Participants were recruited from the Healthy Aging and Biomarkers Cohort Study. Based on baseline information about blood urea nitrogen and risk for frailty obtained at follow-up of the participants, blood urea nitrogen to creatinine ratio was classified according to quintiles, Cox proportional hazard regression models were used to analyze the association between blood urea nitrogen to creatinine ratio and frailty. Results A total of 1 562 participants aged (81.0±17.0) years were included, in whom 814 (52.1%) were men, and 258 frailty events occurred during a mean follow-up of (3.73±1.43) years. Cox proportional hazards model showed that after adjusting for relevant confounders, compared with the participants in the lowest quintile group (Q1), the risk for frailty decreased by 36%, 44%, and 40% in the participants in the third quintile group (Q3), the fourth quintile group (Q4) and the highest quintile group (Q5) respectively [hazard ratio (HR)=0.64, 95%CI: 0.43-0.94; HR=0.56, 95%CI: 0.38-0.84; HR=0.60, 95%CI: 0.41-0.88]. The risk for frailty decreased by 20% for every unit standard deviation increase in blood urea nitrogen to creatinine ratio (HR=0.80, 95%CI: 0.70-0.91). Moreover, blood urea nitrogen to creatinine ratio and the risk for frailty showed a nearly linear dose-response relationship. Conclusions The increase in blood urea nitrogen to creatinine ratio was associated with higher risk for frailty. Maintaining high blood urea nitrogen to creatinine ratio is important for the prevention of frailty in the elderly.
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