四川省居民体力活动对脑血管病发病风险影响的前瞻性研究

周静; 陈晓芳; 常晓宇; 张宁梅; 陈小芳; 伍霞; 刘佳秋; 蒋微; 吕筠; 余灿清; 孙点剑一; 裴培; 吴先萍

Abstract

周静,陈晓芳,常晓宇,张宁梅,陈小芳,伍霞,刘佳秋,蒋微,吕筠,余灿清,孙点剑一,裴培,吴先萍.四川省居民体力活动对脑血管病发病风险影响的前瞻性研究[J].Chinese journal of Epidemiology,2024,45(6):787-793

四川省居民体力活动对脑血管病发病风险影响的前瞻性研究

Relationship between physical activity and the risk of morbidity of cerebrovascular disease in Sichuan Province: a prospective study

Received:November 20, 2023

DOI：10.3760/cma.j.cn112338-20231120-00297

KeyWord: 中国慢性病前瞻性研究体力活动脑血管病

English Key Word: China Kadoorie Biobank Physical activity Cerebrovascular diseases

FundProject:国家自然科学基金（82192900，82192901，82192904，81390540，91846303）；国家重点研发计划精准医学研究重点专项（2016YFC0900500）；中国香港Kadoorie Charitable基金；英国Wellcome Trust（202922/Z/16/Z，088158/Z/09/Z，104085/Z/14/Z）

Author Name	Affiliation	E-mail
Zhou Jing	Institute of Chronic Disease, Sichuan Center for Disease Control and Prevention, Chengdu 610041, China
Chen Xiaofang	Department of Epidemiology & Biostatistics, School of Public Health, Chengdu Medical College, Chengdu 610500, China
Chang Xiaoyu	Institute of Chronic Disease, Sichuan Center for Disease Control and Prevention, Chengdu 610041, China
Zhang Ningmei	Institute of Chronic Disease, Sichuan Center for Disease Control and Prevention, Chengdu 610041, China
Chen Xiaofang	Division of Chronic Disease, Pengzhou Center for Disease Control and Prevention of Sichuan, Pengzhou 611930, China
Wu Xia	Division of Chronic Disease, Pengzhou Center for Disease Control and Prevention of Sichuan, Pengzhou 611930, China
Liu Jiaqiu	Division of Chronic Disease, Pengzhou Center for Disease Control and Prevention of Sichuan, Pengzhou 611930, China
Jiang Wei	Division of Chronic Disease, Pengzhou Center for Disease Control and Prevention of Sichuan, Pengzhou 611930, China
Lyu Jun	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China
Yu Canqing	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China
Sun Dianjianyi	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China
Pei Pei	Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China
Wu Xianping	Health Commission of Sichuan Province, Chengdu 610041, China	wwwuxp@163.com

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Abstract:

目的了解四川省彭州市≥30岁居民脑血管病的发病情况，分析体力活动水平对脑血管病发病风险的影响。方法 2004-2008年随机抽取四川省彭州市30~79岁人群进行问卷调查、体格检查等，并进行长期随访，确定脑血管病发病情况。描述人群中体力活动水平及脑血管病发病情况，采用Cox比例风险回归模型分析不同类型体力活动和脑血管病的关系。结果共纳入55 126名研究对象，其中有5 290名新发脑血管病患者，累积发病率为9.60%。控制多个混杂因素后，多因素Cox比例风险回归模型分析结果显示，工作性、通勤性及总体力活动水平增高可降低脑血管病及其亚型（脑出血、脑梗死）的发病风险。与工作性体力活动水平最低组相比，工作性体力活动水平最高组脑血管病发病风险最低，风险比（HR）值为0.81（95%CI：0.75~0.88）；与通勤性体力活动水平最低组相比，通勤性体力活动水平最高组脑血管病发病风险最低，HR值为0.84（95%CI：0.78~0.91）；与总体力活动水平最低组相比，总体力活动水平最高组脑血管病发病风险最低，HR值为0.87（95%CI：0.80~0.94）；未发现家务性/休闲性体力活动水平与脑血管病及其亚型（脑出血、脑梗死）发病风险间的关联。结论在四川省彭州市，体力活动的增加与脑血管病及其亚型（脑出血、脑梗死）发病率的降低有关，应鼓励增加成年人的体力活动水平，以获得健康益处。

English Abstract:

Objective　To investigate the morbidity of cerebrovascular disease among residents ≥30 years in Pengzhou, Sichuan Province, and analyze the effect of physical activity level on the risk of morbidity of cerebrovascular disease. Methods　From 2004 to 2008, people from Pengzhou, Sichuan Province were randomly selected. All the local people aged 30-79 were asked to receive a questionnaire survey, physical examination, and long-term follow-up to determine the morbidity of cerebrovascular disease. The physical activity level and the morbidity of cerebrovascular disease were described, and Cox proportional hazard regression models were used to evaluate the association of domain-specific physical activity with the risk of morbidity of cerebrovascular disease. Results　In 55 126 participants, there were 5 290 new cases of cerebrovascular disease, with a cumulative incidence of 9.60%. After the adjustment for multiple confounding factors, multivariate Cox proportional hazard regression analysis showed that increased levels of occupational, transportation, and total physical activity reduced the risk of cerebrovascular disease and its subtypes (cerebral hemorrhage, cerebral infarction). The highest group of occupational physical activity level had the lowest risk of cerebrovascular disease, with a hazard ratio (HR) value of 0.81 (95%CI: 0.75-0.88), the highest group of transportation physical activity level had the lowest risk of cerebrovascular disease, with an HR value of 0.84 (95%CI: 0.78-0.91), the highest group of total physical activity level had the lowest risk of cerebrovascular disease, with an HR value of 0.87 (95%CI: 0.80-0.94), compared with the lowest group of corresponding physical activity. No association was found between the household/leisure-time physical activity level and the risk of cerebrovascular disease and its subtypes (cerebral hemorrhage, cerebral infarction). Conclusions　In project areas of Pengzhou, Sichuan Province, increased physical activity has been associated with reduced morbidity of cerebrovascular disease and its subtypes (cerebral hemorrhage, cerebral infarction). Increased levels of physical activity in adults are encouraged for health benefits.

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