浙江省HIV感染者梅毒感染及相关因素分析

何林; 潘晓红; 杨介者; 郑锦雷; 程伟; 柴程良

Abstract

何林,潘晓红,杨介者,郑锦雷,程伟,柴程良.浙江省HIV感染者梅毒感染及相关因素分析[J].Chinese journal of Epidemiology,2024,45(6):839-843

浙江省HIV感染者梅毒感染及相关因素分析

Syphilis infection and related factors among HIV-infected patients in Zhejiang Province

Received:January 17, 2024

DOI：10.3760/cma.j.cn112338-20240117-00022

KeyWord: HIV感染者梅毒感染筛查相关因素

English Key Word: HIV-infected Syphilis Infection Screening Related factor

FundProject:浙江省基础公益研究计划（LGF18H260006）；浙江省医药卫生科技计划（2023KY632，2021RC048）

Author Name	Affiliation	E-mail
He Lin	Institute of AIDS/STD Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Pan Xiaohong	Institute of AIDS/STD Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China Zhejiang Association of STD/AIDS Prevention and Control, Hangzhou 310005, China	xhpan@cdc.zj.cn
Yang Jiezhe	Institute of AIDS/STD Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Zheng Jinlei	Institute of AIDS/STD Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Cheng Wei	Institute of AIDS/STD Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Chai Chengliang	Institute of AIDS/STD Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China

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Abstract:

目的了解浙江省随访>1年HIV感染者梅毒感染及相关因素。方法资料来源于中国疾病预防控制信息系统截至2022年12月31日现住址为浙江省、HIV确证时间>1年、年龄≥15岁HIV感染者，收集其人口学特征、病毒载量和梅毒血清学检测结果等信息。采用logistic回归模型对梅毒感染及相关因素进行分析。采用SPSS 19.0软件进行统计学分析。结果研究对象共33 734例HIV感染者，梅毒感染率为5.6%（1 879/33 734）。在梅毒感染病例中，男性、25~34岁年龄组、未婚者、同性性传播者、外省户籍者和HIV确证前有STD史者的梅毒感染率分别为6.4%（1 774/27 934）、7.5%（640/8 543）、7.6%（1 025/13 423）、8.3%（1 239/14 862）、6.9%（214/3 080）和9.6%（602/6 267）。多因素logistic回归分析结果显示，男性（aOR=2.19，95%CI：1.77~2.72）、25~34岁年龄组（aOR=1.80，95%CI：1.47~2.20）、同性性传播（aOR=1.67，95%CI：1.49~1.88）、外省户籍（aOR=1.26，95%CI：1.09~1.47）、HIV确证前有STD史（aOR=1.98，95%CI：1.78~2.20）为梅毒感染的危险因素。已婚（aOR=0.79，95%CI：0.68~0.92）为梅毒感染的保护因素。结论浙江省随访>1年HIV感染者的梅毒感染率较高，建议对男性、同性性传播和有STD史的HIV感染者加强梅毒监测和筛查频次。

English Abstract:

Objective　To investigate syphilis infection and related factors among HIV-infected patients being followed up for more than one year in Zhejiang Province. Methods　Data were collected from the China Disease Control and Prevention Information System, and information such as demographic characteristics, viral load levels, and syphilis serologic test results was collected from HIV-infected persons who were diagnosed with HIV more than 1 year, aged ≥15 years with a current address in Zhejiang Province through December 31, 2022. The logistic regression model analyzed the prevalence of syphilis and the related factors. The SPSS 19.0 software was used for statistical analysis. Results　A total of 33 734 HIV-infected patients, with the prevalence of syphilis was 5.6% (1 879/33 734). Among the syphilis cases, the prevalence of syphilis was 6.4% (1 774/27 934) of males, 7.5% (640/8 543) of 25-34 years old age group, 7.6% (1 025/13 423) of unmarried, 8.3% (1 239/14 862) of homosexual transmission, 6.9% (214/3 080) with a non-local registered residence and 9.6% (602/6 267) with a history of STD before the HIV diagnosis. Multivariate Logistic regression analysis showed that participants who were male (aOR=2.19, 95%CI:1.77-2.72), 25-34 years old age group (aOR=1.80, 95%CI:1.47-2.20), homosexual transmission (aOR=1.67, 95%CI:1.49-1.88), with other provinces registered residence (aOR=1.26, 95%CI:1.09-1.47), and with a history of sexually transmitted disease (STD) before the HIV diagnosis (aOR=1.98, 95%CI:1.78-2.20) were associated with increased risk of syphilis. Being married (aOR=0.79, 95%CI:0.68-0.92) was associated with a decreased risk of syphilis. Conclusions　Syphilis infections were high in HIV-infected patients followed up more than one year in Zhejiang Province. It is recommended that syphilis surveillance and screening frequency should be strengthened among HIV-infected persons with characteristics such as male, homosexual transmission, and STD history.

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