| 韩书婕,陈守航,戴博雯,陈雨,韩淑娟,张如玉,王臣玉,王青梅,郑嘉颖,段广才,王芳,晋乐飞.河南省2012-2023年儿童青少年病毒性脑炎的流行病学特征分析[J].Chinese journal of Epidemiology,2024,45(6):852-856 |
| 河南省2012-2023年儿童青少年病毒性脑炎的流行病学特征分析 |
| Epidemiological characteristic of viral encephalitis in children and adolescents in Henan Province, 2012-2023 |
| Received:October 18, 2023 |
| DOI：10.3760/cma.j.cn112338-20231018-00235 |
| KeyWord: 病毒性脑炎 肠道病毒 柯萨奇病毒 儿童青少年 |
| English Key Word: Viral encephalitis Enterovirus Coxsackie virus Children and adolescents |
| FundProject:国家自然科学基金（82372229，82002147） |
| Author Name | Affiliation | E-mail | | Han Shujie | Department of Infectious Diseases, Zhengzhou Children's Hospital/Henan Provincial Children's Hospital, Zhengzhou 450018, China
Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China | | | Chen Shouhang | Department of Infectious Diseases, Zhengzhou Children's Hospital/Henan Provincial Children's Hospital, Zhengzhou 450018, China | | | Dai Bowen | Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China | | | Chen Yu | Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China | | | Han Shujuan | Department of Infectious Diseases, Zhengzhou Children's Hospital/Henan Provincial Children's Hospital, Zhengzhou 450018, China | | | Zhang Ruyu | Department of Infectious Diseases, Zhengzhou Children's Hospital/Henan Provincial Children's Hospital, Zhengzhou 450018, China | | | Wang Chenyu | Department of Infectious Diseases, Zhengzhou Children's Hospital/Henan Provincial Children's Hospital, Zhengzhou 450018, China | | | Wang Qingmei | Department of Infectious Diseases, Zhengzhou Children's Hospital/Henan Provincial Children's Hospital, Zhengzhou 450018, China | | | Zheng Jiaying | Department of Infectious Diseases, Zhengzhou Children's Hospital/Henan Provincial Children's Hospital, Zhengzhou 450018, China | | | Duan Guangcai | Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China | | | Wang Fang | Department of Infectious Diseases, Zhengzhou Children's Hospital/Henan Provincial Children's Hospital, Zhengzhou 450018, China | 13783637576@139.com | | Jin Yuefei | Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China | jyf201907@zzu.edu.cn |
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| Abstract: |
| 目的 分析2012-2023年河南省儿童青少年病毒性脑炎流行特征及其时空变化趋势分布。方法 以河南省儿童医院/郑州儿童医院（国家儿童区域医疗中心）为研究现场，收集入院时间为2012年10月1日至2023年7月26日的病毒性脑炎病例信息，分析病例的时空分布特征、重症发生率、年龄构成、病原构成和影像学检查结果的情况。结果 本研究排除信息不全的病毒性脑炎病例后共纳入6 276例。病例主要来源于郑州市（38.96%），其次分别为周口市（9.93%）、许昌市（8.68%）、驻马店市（7.90%）和平顶山市（7.39%）。病例中男性占62.13%，女性占37.87%，7~13岁病例数最多（72.45%）。2012-2023年总体重症率为4.51%，不同地区、年份的重症构成比差异有统计学意义（χ2=5.33，P=0.021； χ2=48.14，P<0.001）。病原分型中肠道病毒构成比最大（31.57%），其中柯萨奇病毒居多（58.37%）。影像学检查结果表明，儿童青少年患病毒性脑炎大脑半球的损伤最常见（54.93%）。结论 2012-2023年河南省病毒性脑炎病例中男性较多，7~13岁儿童青少年为主要发病人群，肠道病毒尤其是柯萨奇病毒感染应当引起重视，在诊断病毒性脑炎后要特别注意预防大脑半球的损伤。 |
| English Abstract: |
| Objective To understand the epidemiological characteristics and spatiotemporal distribution of viral encephalitis in children and adolescents in Henan Province from 2012 to 2023. Methods The information about viral encephalitis cases from October 1, 2012 to July 26, 2023 were collected from Zhengzhou Children's Hospital (National Children's Regional Medical Center),Henan Provincial Children's Hospital for the analyses on temporal distribution the cases, the severe illness rate, age distribution, pathogen type and imaging findings of the cases.Results A total of 6 276 cases of viral encephalitis were included in this study after excluding cases with incomplete information. The cases mainly originated from Zhengzhou (38.96%), followed by Zhoukou (9.93%), Xuchang (8.68%), Zhumadian (7.90%) and Pingdingshan (7.39%). The cases in boys accounted for 62.13% and the cases in girls accounted for 37.87%. Most cases (72.45%) occurred in age group 7-13 years. The overall rate of severe illness cases was 4.51% from 2012 to 2023. There were significant differences in severe illness cases among different areas and years (χ2=5.33,P=0.021; χ2=48.14,P<0.001). Enteroviruses were mainly detected (31.57%), in which Coxsackie virus was predominant (58.37%). Imaging findings showed that cerebral hemisphere damage was most common in children and adolescents with viral encephalitis (54.93%). Conclusions From 2012 to 2023, more cases of viral encephalitis occurred in boys in Henan. Children and adolescents aged 7-13 years were the main affected group. The prevention of enteroviruses infection, especially Coxsackie virus, needs to be strengthened. Special attention should be paid to the prevention of cerebral hemisphere damage after viral encephalitis diagnosis. |
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