| 庞官连,马志敏,诸铭轩,葛文静,牟园淋,王国庆,朱兆鹏,李樵,朱猛.母亲孕期吸烟及子代遗传风险与全肿瘤死亡风险的队列研究[J].Chinese journal of Epidemiology,2024,45(8):1045-1051 |
| 母亲孕期吸烟及子代遗传风险与全肿瘤死亡风险的队列研究 |
| A cohort study of maternal smoking during pregnancy, offspring genetic risk, and overall cancer mortality |
| Received:February 21, 2024 |
| DOI：10.3760/cma.j.cn112338-20240221-00078 |
| KeyWord: 母亲孕期吸烟 多基因风险评分 全肿瘤死亡风险 前瞻性队列研究 |
| English Key Word: Maternal smoking during pregnancy Polygenic risk score Overall cancer mortality Prospective cohort study |
| FundProject:江苏省优秀青年基金（BK20220100） |
| Author Name | Affiliation | E-mail | | Pang Guanlian | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Ma Zhimin | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Zhu Mingxuan | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Ge Wenjing | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Mou Yuanlin | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Wang Guoqing | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Zhu Zhaopeng | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Li Qiao | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Zhu Meng | Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, China | zhmnjmu@njmu.edu.cn |
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| Abstract: |
| 目的 探讨母亲孕期吸烟和子代遗传易感性对全肿瘤死亡风险的独立和综合影响。方法 基于英国生物银行（n=419 228）数据，使用Cox比例风险回归模型估计母亲孕期吸烟对子代全肿瘤（包括男性16种和女性18种恶性肿瘤）死亡风险的影响，并分析母亲孕期吸烟与子代遗传因素的联合效应和交互作用。结果 母亲孕期吸烟与子代全肿瘤死亡风险的增加显著相关，其中男性增加13%［风险比（HR）=1.13，95%CI：1.06~1.20］，女性增加19%（HR=1.19，95%CI：1.11~1.27）。与低遗传风险者相比，高遗传风险者的全肿瘤死亡风险最高（男性：HR=1.42，95%CI：1.30~1.55；女性：HR=1.38，95%CI：1.25~1.52）。与母亲孕期未吸烟、低遗传风险的参与者相比，母亲孕期吸烟且高遗传风险的男性全肿瘤死亡风险增加56%（HR=1.56，95%CI：1.37~1.77），女性增加59%（HR=1.59，95%CI：1.39~1.83）。结论 母亲孕期吸烟可能会增加子代的全肿瘤死亡风险，且在高遗传风险的个体中母亲孕期吸烟的危害更严重。 |
| English Abstract: |
| Objective To investigate the independent and combined effects of maternal smoking during pregnancy and offspring genetic susceptibility on overall cancer mortality.Methods Based on the United Kingdom Biobank (n=419 228) data, the Cox proportional hazard regression model was used to estimate the effect of maternal smoking during pregnancy on offspring overall cancer (including 16 cancers in men and 18 in women) mortality and its combined effect and interaction with offspring genetic factors.Results Maternal smoking during pregnancy was significantly associated with a 13% increased risk of overall cancer mortality in men [hazard ratio(HR)=1.13, 95%CI: 1.06-1.20] and 19% increased risk in women (HR=1.19, 95%CI: 1.11-1.27). Participants with high genetic risk had the highest overall cancer mortality than those with low genetic risk (men: HR=1.42, 95%CI: 1.30-1.55; women: HR=1.38, 95%CI: 1.25-1.52). Compared with participants without maternal smoking during pregnancy and low genetic risk, those with maternal smoking during pregnancy and high genetic risk were associated with a 56% increased risk of overall cancer mortality in men (HR=1.56, 95%CI: 1.37-1.77) and 59% in women (HR=1.59, 95%CI: 1.39-1.83).Conclusion Maternal smoking during pregnancy may increase offspring overall cancer mortality and more severe harm in individuals with high genetic risk. |
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