| 张春发,李乐慧,张楠,曹宁,许蕾,闫金利,王雅,赵昕玥,杨雨心,闫涛,张星光.成年人衰弱指数与心血管疾病发病风险的关联研究[J].Chinese journal of Epidemiology,2024,45(11):1520-1527 |
| 成年人衰弱指数与心血管疾病发病风险的关联研究 |
| Association of frailty index with the risk for cardiovascular disease in adults |
| Received:April 27, 2024 |
| DOI：10.3760/cma.j.cn112338-20240427-00222 |
| KeyWord: 衰弱指数 心血管疾病 前瞻性队列研究 |
| English Key Word: Frailty index Cardiovascular disease Prospective cohort study |
| FundProject:国家自然科学基金（82160639）；内蒙古自治区卫生健康委员会项目（202201227）；内蒙古医科大学面上项目（YKD2022MS079）；内蒙古医科大学学科建设项目（YKD2023XK015）；内蒙古自治区教育厅项目（NJZY22645）；内蒙古医科大学科技创新团队项目（YKD2022TD015）；内蒙古自然科学基金（2023QN08030，2024QN08016，2024MS08016，2024MS08074）；内蒙古自治区高等学校科学研究项目（NJZY22617） |
| Author Name | Affiliation | E-mail | | Zhang Chunfa | Department of Biostatistics, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China | | | Li Lehui | Department of Environmental Health, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China | | | Zhang Nan | Department of Health Inspection and Quarantine, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China | | | Cao Ning | Department of Epidemiology, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China | | | Xu Lei | Department of Biostatistics, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China | | | Yan Jinli | Department of Biostatistics, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China | | | Wang Ya | Department of Biostatistics, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China | | | Zhao Xinyue | Department of Biostatistics, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China | | | Yang Yuxin | Department of Hygiene Toxicology, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China | | | Yan Tao | Department of Biostatistics, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China | | | Zhang Xingguang | Department of Biostatistics, School of Public Health, Inner Mongolia Medical University, Hohhot 010110, China | zxg311@126.com |
|
| Hits: 218 |
| Download times: 65 |
| Abstract: |
| 目的 探究成年人衰弱指数（FI）与心血管疾病（CVD）发病风险的关联，为内蒙古自治区成年人预防CVD提供新的依据。方法 利用经历6年随访、样本量为25 055名的前瞻性队列数据构建FI，通过FI对成年人的衰弱情况进行描述，采用Cox比例风险回归模型分析成年人FI与CVD发病风险的关联。结果 研究人群的FI为0.24±0.09。与非衰弱（FI≤0.20）人群相比，衰弱前期（FI：0.21~0.27）和衰弱期（FI≥0.28）人群CVD发病风险增加［衰弱前期：风险比（HR）=1.232，95%CI：1.127~1.347；衰弱期：HR=1.418，95%CI：1.299~1.548］。FI每增加0.10，CVD的发病风险增加20.3%（HR=1.203，95%CI：1.156~1.252）。结论 本研究构建了FI，该指标与CVD发病风险增加相关。随着衰弱程度加重，CVD发病风险随之升高。 |
| English Abstract: |
| Objective To explore the association between frailty index (FI) and the risk for cardiovascular disease (CVD) in adults in Inner Mongolia Autonomous Region, and provide new evidence for the prevention of CVD in adults in Inner Mongolia Autonomous Region. Methods The FI was constructed by using the data from a prospective cohort with a sample size of 25 055 individuals in 6 years of follow-up, and the prevalence of frailty in adults in Inner Mongolia Autonomous Region was described by the FI, and Cox proportional hazard regression model was used to evaluate the association between the FI and the incidence of CVD in adults in Inner Mongolia Autonomous Region. Results The FI of the study population was 0.24±0.09. The population in the pre-frail (FI: 0.21-0.27) and frail (FI≥0.28) phases had increased risk for CVD compared to non-frail (FI≤0.20) population [pre-frail: hazard ratio (HR)=1.232, 95%CI: 1.127-1.347; frail phase: HR=1.418, 95%CI:1.299-1.548]. For every 0.10 increase in FI, the risk for cardiovascular disease increased by 20.3% (HR=1.203,95%CI:1.156-1.252). Conclusions In this study, we constructed a FI, which can suggest the risk for CVD. As the increase of frailty degree, the risk for CVD increases. |
|
View Fulltext
Html FullText
View/Add Comment Download reader |
| Close |
|
|
|