| 陈昭云,赵清霞,杨萱,邓萌,赵淑娴,刘春礼,侯明杰,张志会,李琼,孙燕.河南省2023年HIV感染者常见慢性病患病情况及相关因素分析[J].Chinese journal of Epidemiology,2025,46(2):258-263 |
| 河南省2023年HIV感染者常见慢性病患病情况及相关因素分析 |
| Prevalence of common chronic diseases and related factors in HIV-infected persons in Henan Province, 2023 |
| Received:June 26, 2024 |
| DOI：10.3760/cma.j.cn112338-20240626-00375 |
| KeyWord: HIV感染者 高脂血症 高血压 糖尿病 抗病毒治疗 |
| English Key Word: HIV-infected persons Hyperlipidemia Hypertension Diabetes Antiviral therapy |
| FundProject:河南省科技攻关项目（242102310204）；郑州市医疗卫生领域科技创新指导计划（2024YLZDJH380）；河南省传染病（艾滋病）临床医学研究中心开放课题（KFKT202411） |
| Author Name | Affiliation | E-mail | | Chen Zhaoyun | Henan Provincial Hospital of Infectious Diseases (The Sixth People's Hospital of Zhengzhou), Zhengzhou 450000, China
Office of Henan Provincial Clinical Research Center for Infectious Diseases (AIDS), Zhengzhou 450000, China | | | Zhao Qingxia | Henan Provincial Hospital of Infectious Diseases (The Sixth People's Hospital of Zhengzhou), Zhengzhou 450000, China | | | Yang Xuan | Henan Provincial Hospital of Infectious Diseases (The Sixth People's Hospital of Zhengzhou), Zhengzhou 450000, China | | | Deng Meng | Henan Provincial Hospital of Infectious Diseases (The Sixth People's Hospital of Zhengzhou), Zhengzhou 450000, China
Office of Henan Provincial Clinical Research Center for Infectious Diseases (AIDS), Zhengzhou 450000, China | | | Zhao Shuxian | Henan Provincial Hospital of Infectious Diseases (The Sixth People's Hospital of Zhengzhou), Zhengzhou 450000, China | | | Liu Chunli | Henan Provincial Hospital of Infectious Diseases (The Sixth People's Hospital of Zhengzhou), Zhengzhou 450000, China | | | Hou Mingjie | Henan Provincial Hospital of Infectious Diseases (The Sixth People's Hospital of Zhengzhou), Zhengzhou 450000, China | | | Zhang Zhihui | Henan Provincial Hospital of Infectious Diseases (The Sixth People's Hospital of Zhengzhou), Zhengzhou 450000, China
Office of Henan Provincial Clinical Research Center for Infectious Diseases (AIDS), Zhengzhou 450000, China | | | Li Qiong | Henan Provincial Hospital of Infectious Diseases (The Sixth People's Hospital of Zhengzhou), Zhengzhou 450000, China
Office of Henan Provincial Clinical Research Center for Infectious Diseases (AIDS), Zhengzhou 450000, China | | | Sun Yan | Henan Provincial Hospital of Infectious Diseases (The Sixth People's Hospital of Zhengzhou), Zhengzhou 450000, China | sunyan2005@126.com |
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| Abstract: |
| 目的 分析2023年河南省HIV感染者常见慢性病（高脂血症、高血压和糖尿病）患病情况及相关因素。方法 截至2023年12月，以河南省接受抗病毒治疗（ART）及随访年龄>15岁的HIV感染者为研究对象，开展问卷调查、体检和采集血样，收集研究对象的人口学信息、ART、体重、血脂、血压和血糖等资料。采用logistic回归模型分析高脂血症、高血压和糖尿病的相关因素。结果 在HIV感染者4 023例中，高脂血症、高血压和糖尿病患病率分别为64.47%（2 594/4 023）、16.80%（676/4 023）、10.54%（424/4 023）。多因素分析结果显示，高脂血症与≥40岁年龄组、超重和肥胖、使用2种核苷类反转录酶抑制剂（NRTIs）+蛋白酶抑制剂（PIs）治疗方案和2种NRTIs+整合酶抑制剂治疗方案呈正相关，与低体重呈负相关；高血压与≥40岁年龄组、心脑血管疾病家族史、超重和肥胖、ART时间≥0.5年呈正相关，与低体重呈负相关；糖尿病与≥40岁年龄组、心脑血管疾病家族史、超重和肥胖呈正相关，与使用2种NRTIs+PIs治疗方案呈负相关。结论 2023年河南省HIV感染者高脂血症、高血压和糖尿病的患病率较高，≥40岁年龄组、超重和肥胖、有心脑血管疾病家族史者的常见慢性病的患病风险较高，建议加强HIV感染者常见慢性病的预防和管理。 |
| English Abstract: |
| Objective To understand the prevalence and related factors of three common chronic diseases, hyperlipidemia, hypertension and diabetes in HIV-infected persons. Methods As of December 2023, HIV-infected persons >15 years old who are receiving antiviral therapy (ART) and follow-up in Henan Province were selected as the study objects. Questionnaires, physical examinations, and blood samples were collected to collect demographic information, ART, body weight, blood lipids, blood pressure, and blood sugar of HIV-infected persons. The logistic regression model was used to analyze the related factors of hyperlipidemia, hypertension and diabetes.Results Among 4 023 HIV-infected patients, the prevalence rates of hyperlipidemia, hypertension, and diabetes were 64.47% (2 594/4 023), 16.80% (676/4 023), and 10.54% (424/4 023), respectively. Multivariate analysis showed that hyperlipidemia was positively associated with ≥40 years of age, overweight and obesity, two nucleoside reverse transcriptase inhibitors (NRTIs) + proteasome inhibitors (PIs) regimen and two NRTIs+ integrase inhibitor regimen, and negatively associated with low body weight. Hypertension was positively correlated with the age group ≥40 years old, family history of cardiovascular and cerebrovascular diseases, overweight and obesity, ART time ≥0.5 years, and negatively correlated with low body weight. Diabetes was positively associated with age group ≥40 years, family history of cardiovascular and cerebrovascular disease, overweight and obesity, and negatively associated with the use of two NRTIs+PIs treatment regimens.Conclusions In 2023, the prevalence of hyperlipidemia, hypertension, and diabetes among HIV-infected people in Henan Province was relatively high, and the risk of common chronic diseases among those ≥40 years old, overweight and obese, and those with a family history of cardiovascular and cerebrovascular diseases was also relatively high. It is recommended to strengthen the prevention and management of common chronic diseases among HIV-infected people. |
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