车莉,卢竞,鲁杰,赵小元,刘小燕.肺炎支原体下呼吸道感染患儿血清肿瘤坏死因子-α、白细胞介素-8的检测[J].Chinese journal of Epidemiology,1999,20(1):50-52 |
肺炎支原体下呼吸道感染患儿血清肿瘤坏死因子-α、白细胞介素-8的检测 |
Measurement of serum tumor necrosis factor-αand interleukin-8 in children with low respiratorytract infection (LRTI) caused by Mycoplasma pneumonia |
Received:September 29, 1998 Revised:October 27, 1998 |
DOI: |
KeyWord: 支原体.肺炎 肿瘤坏死因子 白细胞介素-8 |
English Key Word: Mycoplasa pneumonia Tumor necrosis factor Interleukin-8 |
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Abstract: |
目的 探索肺炎支原体所致下呼吸道感染的免疫学发病机制。方法 采用顺序饱和液相竞争放射免疫分析法及夹心酶免疫放射分析法对30 例肺炎支原体所致下呼吸道感染患儿血清进行了肿瘤坏死因子(TNF)-α和白细胞介素-8( I L-8) 的检测。结果 肺炎支原体所致下呼吸道感染患儿血清中 T N F-α及 I L-8 水平均明显高于健康儿童; T N F-α和 I L-8 升高呈正相关。结论 T N F-α在肺炎支原体所致下呼吸道感染中起着重要作用,也是 I L-8 升高的重要促进因子。 |
English Abstract: |
Objective To investigate the immunopathological mechanism of LRTI caused by Mycoplasma pneumonia.Methods Serum tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) from 30 patients with LRTI caused by Mycoplasma pneumonia, were measured with sequence saturated solution competitive radioimmunoassay and sandwich ELISA.Results The level of serum TNF-α and IL-8 of patients suffering from LRTI caused by Mycoplasma pneumonia were magnificently higher than that of healthy children. Meanwhile, a positive relationship between serum TNF-α and IL-8 was noticed.Conclusion TNF-αplays an important role in LRTI caused by Mycoplasma pneumonia, and serves the key factor to the elevation of IL-8. |
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