中国2007-2016年59岁以下普通人群HBsAg阳性率的Meta分析

张维璐; 吉兆华; 付婷; 张磊; 苏海霞; 闫永平

Abstract

张维璐,吉兆华,付婷,张磊,苏海霞,闫永平.中国2007-2016年59岁以下普通人群HBsAg阳性率的Meta分析[J].Chinese journal of Epidemiology,2017,38(9):1278-1284

中国2007-2016年59岁以下普通人群HBsAg阳性率的Meta分析

Meta analysis on HBsAg-positive rate among general populations aged 1-59 years, 2007-2016, China

Received:October 14, 2016

DOI：10.3760/cma.j.issn.0254-6450.2017.09.027

KeyWord: 乙型肝炎表面抗原阳性率 Meta分析

English Key Word: HBsAg Positive rate Meta-analysis

FundProject:国家自然科学基金（81473026，81302474）；国家科技重大专项（2012ZX10004907）；陕西省社发攻关项目（2016SF-131）

Author Name	Affiliation	E-mail
Zhang Weilu	Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China
Ji Zhaohua	Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China
Fu Ting	Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China
Zhang Lei	Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China
Su Haixia	Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China
Yan Yongping	Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China	yanyping@fmmu.edu.cn

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Abstract:

目的采用Meta分析方法系统评价2007-2016年中国59岁以下普通人群HBsAg阳性率的变化趋势。方法通过中国知网（CNKI）、维普中文科技期刊全文数据库（VIP）及PubMed，系统检索2007年1月至2016年8月中国59岁以下普通人群HBsAg阳性率的文献，采用comprehensive Meta-analysis 2.2软件，运用固定效应模型和随机效应模型合并分析59岁以下普通人群HBsAg阳性率。结果共纳入文献46篇，总样本量625 053例，Meta分析结果显示中国59岁以下普通人群HBsAg阳性率为5.7%（95%CI：4.8%~6.6%）。中西部地区59岁以下普通人群HBsAg阳性率为6.3%（95%CI：4.9%~8.0%），高于东部地区的5.5%（95%CI：4.4%~6.8%）。59岁以下男性人群HBsAg阳性率为6.1%（95%CI：5.3%~7.0%），高于女性人群的4.8%（95%CI：4.2%~5.5%）。2007-2009年的59岁以下普通人群HBsAg阳性率为6.3%（95%CI：5.5%~7.2%），2010-2012年为5.9%（95%CI：4.4%~8.0%），2013-2016年为3.5%（95%CI：2.0%~6.1%）。结论 2007-2016年中国59岁以下普通人群HBsAg阳性率呈现下降趋势，已经从乙型肝炎高流行区转变为乙型肝炎中流行区。

English Abstract:

Objective To perform a Meta-analysis on hepatitis B surface antigen (HBsAg)-positive rates among general Chinese population aged 1-59 years. Methods We systemically reviewed the related data (January 2007 to August 2016) published from Chinese National Knowledge Infrastructure (CNKI), VIP, and PubMed. We also assessed the HBsAg-positive rates among general Chinese populations aged 1-59 years, using a random effects regression model with the comprehensive Meta-analysis software 2.2. Results A total of 46 papers were finally included, with a total sample size of 625 053 individuals. Results from the Meta-analysis showed that the overall combined HBsAg-positive rate was 5.7% (95%CI:4.8%-6.6%) among general Chinese populations aged 1-59 years. When comparing the HBsAg-positive rates in different regions, data showed that the HBsAg-positive rate of was higher in the mid-western areas (6.3%, 95%CI:4.9%-8.0%) than in the eastern areas (5.5%, 95%CI:4.4%-6.8%). Results showed that HBsAg-positive rates was higher in males (6.1%, 95%CI:5.3%-7.0%) than in females (4.8%, 95%CI:4.2%-5.5%). As for the HBsAg-positive rates in different time periods, data showed positive rate of 6.3% (95%CI:5.5%-7.2%) in 2007-2009, 5.9% (95%CI:4.4%-8.0%) in 2010-2012 and 3.5% (95%CI:2.0%-6.1%) in 2013-2016, respectively. Conclusion The prevalence of hepatitis B virus infection was decreasing between 2007 and 2016 in China, making the country an intermediate endemic area on HBV.

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