上海市成年双生子健康生活方式与肥胖的关联研究

周荣飞; 朱珍妮; 汪正园; 臧嘉捷; 贾晓东; 吕筠; 李立明; 吴凡

Abstract

周荣飞,朱珍妮,汪正园,臧嘉捷,贾晓东,吕筠,李立明,吴凡.上海市成年双生子健康生活方式与肥胖的关联研究[J].Chinese journal of Epidemiology,2023,44(6):862-867

上海市成年双生子健康生活方式与肥胖的关联研究

A case-control study on the association between a healthy lifestyle and obesity among adult twins in Shanghai

Received:November 14, 2022

DOI：10.3760/cma.j.cn112338-20221114-00970

KeyWord: 超重肥胖双生子病例对照研究

English Key Word: Overweight Obesity Twins Case-control study

FundProject:卫生行业科研专项（201502006，201002007）

Author Name	Affiliation	E-mail
Zhou Rongfei	School of Public Health, Fudan University, Shanghai 200032, China
Zhu Zhenni	Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
Wang Zhengyuan	Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
Zang Jiajie	Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
Jia Xiaodong	Shanghai Chemical Industry Park Medical Center, Shanghai 201507, China
Lyu Jun	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Li Liming	Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Wu Fan	School of Public Health, Fudan University, Shanghai 200032, China	wufan@shmu.edu.cn

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Abstract:

目的分析上海市成年双生子健康生活方式的数量与超重/肥胖及腹型肥胖的关联。方法使用2017-2018年上海市双生子项目第二轮调查数据，通过病例对照的研究设计分析健康生活方式与肥胖的关联，并进一步利用双生子配对控制遗传等混杂因素。结果共纳入7 864名（3 932对）成年双生子。同卵双生子配对病例对照分析显示，与0~2种健康生活方式者相比，有3种和4~5种健康生活方式者患超重/肥胖的风险分别降低49%（OR=0.51，95%CI：0.28~0.93）和70%（OR=0.30，95%CI：0.13~0.69），患腹型肥胖的风险分别降低17%（OR=0.83，95%CI：0.44~1.57）和66%（OR=0.34，95%CI：0.14~0.80）；并且每增加1种健康生活方式，患超重/肥胖的风险降低41%（OR=0.59，95%CI：0.42~0.85），患腹型肥胖的风险降低37%（OR=0.63，95%CI：0.44~0.90）。结论健康生活方式的数量与超重/肥胖及腹型肥胖均相关，数量越多，患病风险越低。

English Abstract:

Objective To investigate the associations between the numbers of healthy lifestyles and overweight/obesity and abdominal obesity in adult twins in Shanghai. Methods Based on the Shanghai Twin Registry System Phase Ⅱ survey data in 2017-2018, a case-control study was conducted to analyze the association between healthy lifestyles and obesity and further adjusted for confounders by a co-twin control study. Results A total of 7 864 adult twins (3 932 pairs) were included. In the co-twin case-control analysis for monozygotic twins, compared with participants with 0 to 2 healthy lifestyles, those with 3 and 4 to 5 healthy lifestyles had a 49% (OR=0.51, 95%CI: 0.28-0.93) and 70% (OR=0.30, 95%CI: 0.13-0.69) lower risk of overweight/obesity, respectively, and a 17% (OR=0.83, 95%CI: 0.44-1.57) and 66% (OR=0.34, 95%CI: 0.14-0.80) lower risk of abdominal obesity, respectively. For each additional healthy lifestyle, the risk of developing overweight/obesity was reduced by 41% (OR=0.59, 95%CI: 0.42-0.85), and the risk of developing abdominal obesity was reduced by 37% (OR=0.63, 95%CI: 0.44-0.90). Conclusion An increasing number of healthy lifestyles was associated with a marked decreased risk for both overweight/obesity and abdominal obesity.

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